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Updated: Jun 12, 2026

Procedures for In Vitro Cultivation of Treponema pallidum, the Syphilis Spirochete
Published on: January 24, 2025
[Syphilis in children--the outcome of lacking vigilance and insufficient diagnostics]
Jarosław Gruszka1, Leszek Szenborn
1Katedra i Klinika Pediatrii i Chorób Infekcyjnych Dzieci Akademia Medyczna we Wrocławiu. mjgruszka@O2.pl
Insights
Congenital syphilis screening and treatment in Lower Silesia remain insufficient. Inadequate prenatal screening and treatment of Treponema pallidum in pregnant women lead to increased congenital syphilis cases in newborns.
Area of Science:
- Neonatal infections
- Pediatric infectious diseases
- Maternal-fetal medicine
Context:
- Congenital syphilis (CS) poses a significant public health challenge, particularly in regions with suboptimal screening and treatment protocols.
- An increasing trend of CS cases was observed between 2000-2006, followed by a temporary decline, and a subsequent resurgence in 2009, highlighting persistent issues.
Purpose:
- To investigate the causes of rising congenital syphilis morbidity in Lower Silesia.
- To evaluate the prevalence of syphilis screening during pregnancy and the adequacy of treatment according to Polish Gynaecological Society (PTG) recommendations.
- To inform neonatologists, pediatricians, and obstetricians about findings to improve management.
Summary:
- A retrospective analysis of 87 children hospitalized for suspected CS (2002-2009) revealed inadequate prenatal syphilis screening and inconsistent/omitted treatment in a significant proportion of mothers.
- While no cases were diagnosed in 2007-2008, 2009 saw a rise, with 20% of exposed infants infected.
- Mothers of infected infants frequently missed prenatal screening or received non-standard treatment, indicating systemic failures.
Impact:
- Highlights critical gaps in syphilis screening and treatment protocols for pregnant women in Lower Silesia.
- Underscores the urgent need for enhanced educational initiatives targeting healthcare providers involved in maternal and child care.
- Emphasizes the necessity of improved communication and data sharing between obstetricians and pediatric/neonatal teams regarding syphilis management.
Introduction:
In the years from 2000 to 2006 our department managed an increasing number of children exposed to congenital infection or with actual Treponema pallidum infection. Our team analyzed the causes, and published the conclusions addressing pediatricians as well as obstetricians. In the years from 2007 to 2008 we did not find any new cases of syphilis in children. However, despite our educational efforts, 2009 brought an increase of incidence of the disease. The aim of this paper was to establish the causes of new morbidity of congenital syphilis, and consequently spread the obtained information to neonatologists, pediatricians and obstetricians.
Material And Methods:
87 children were hospitalized due to suspicion of congenital syphilis in the years from 2002 to 2009. The analyzed issues were: number of infected children in consecutive years, prevalence of screening to syphilis in pregnancy, and adequacy of treatment according to recommendations of Polish Gynaecological Society (PTG).
Results:
From 2000 to 2006 syphilis was confirmed in 13/45 (28.9%) suspected children. In 2007 and 2008 we did not establish any positive diagnoses. In 2009, we confirmed infection in 3/15 (20%) perinatally exposed children. In the following periods: 2002-2006, 2007-2008 and in 2009, consecutively 6/45, 1/27 and 4/15 mothers were not screened to syphilis during pregnancy, 17/45, 11/27 and 4/15 were treated differently than recommended by PTG, 6/45, 9/27 and 5/15 did not receive any treatment. In 7 cases it was not possible to retrace medical management during pregnancy.
Conclusions:
Screening to syphilis in pregnancy in Lower Silesia is insufficient, and in detected cases the treatment is inadequate or completely omitted. There is still need for education, and also for proper data flow from obstetricians to neonatologists and pediatricians about cases of syphilis detected during pregnancy.
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