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Screening-detected and symptomatic untreated celiac children show similar gut microflora-associated characteristics

Bo Tjellström1, Lars Stenhammar, Lotta Högberg

  • 1Department of Microbiology, Tumor and Cell Biology, Karolinska Institut, Stockholm, Sweden. bo.tjellstrom@ki.se

Scandinavian Journal of Gastroenterology
|June 1, 2010
PubMed

Insights

Children with screening-detected celiac disease (CD) show aberrant gut flora, similar to symptomatic CD. This finding in fecal short-chain fatty acid (SCFA) profiles suggests common disease mechanisms.

Area of Science:

  • Gastroenterology
  • Microbiology
  • Pediatrics

Background:

  • Celiac disease (CD) is an autoimmune disorder triggered by gluten ingestion.
  • Intestinal microflora alterations are implicated in CD pathogenesis.
  • Screening-detected CD represents an early stage of the disease.

Purpose of the Study:

  • To investigate the metabolic function of intestinal microflora in children with screening-detected CD.
  • To compare the gut flora profile of screening-detected CD with symptomatic CD and healthy controls.
  • To determine if aberrant gut flora is present in early-stage CD.

Main Methods:

  • Screening of 912 12-year-old children for CD using serum anti-human tissue transglutaminase-IgA.
  • Analysis of 17 children with biopsy-confirmed CD.
  • Fecal short-chain fatty acid (SCFA) analysis via gas-liquid chromatography.
  • Comparison with previously published data from symptomatic CD and healthy children.

Main Results:

  • Children with screening-detected CD exhibited a fecal SCFA profile similar to those with symptomatic CD.
  • The SCFA profile in screening-detected CD differed significantly from that of healthy children.
  • Aberrant gut microflora metabolic function is present even in early, asymptomatic CD.

Conclusions:

  • This study provides the first evidence of SCFA patterns in fecal samples from children with screening-detected CD.
  • The similar SCFA profiles suggest shared pathogenic mechanisms between screening-detected and symptomatic CD.
  • Findings may inform future therapeutic or prophylactic strategies targeting gut microflora in celiac disease.
Abstract

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