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Published on: August 19, 2025
Serum prohepcidin level in myelodysplasia
Noha M El Husseiny1, Mervat M Matter, Randa M Sabry
1Clinical Hematology Unit, Cairo University, Egypt. dr_noha2002@yahoo.com
Summary
Pro-hepcidin levels are elevated in myelodysplastic syndrome (MDS) patients compared to healthy individuals. Ineffective erythropoiesis, not blood transfusions, primarily regulates pro-hepcidin in MDS.
Area of Science:
- Hematology
- Iron Metabolism
- Hormone Regulation
Background:
- Myelodysplastic syndromes (MDS) are a group of clonal hematopoietic stem cell disorders.
- Iron overload is a common complication in MDS, impacting patient prognosis.
- Hepcidin and its precursor, pro-hepcidin, are key regulators of systemic iron homeostasis.
Purpose of the Study:
- To investigate the role of pro-hepcidin in the iron profile of myelodysplastic syndrome (MDS) patients.
- To compare pro-hepcidin levels between MDS patients and healthy controls.
- To explore factors influencing pro-hepcidin levels in MDS.
Main Methods:
- Cross-sectional study comparing 30 adult MDS patients with 20 healthy adult controls.
- Measurement of serum pro-hepcidin levels.
- Analysis of correlations between pro-hepcidin and hematocrit, age, gender, MDS subtypes, soluble transferrin receptor (sTFR), and ferritin.
Main Results:
- Significantly higher pro-hepcidin levels were observed in MDS patients compared to controls (p = 0.003).
- A weak positive correlation between pro-hepcidin and hematocrit was found in healthy individuals (p = 0.02), but not in MDS patients.
- Pro-hepcidin levels in MDS were independent of age, gender, MDS subtypes, sTFR, or ferritin.
Conclusions:
- Pro-hepcidin is elevated in MDS patients, suggesting its involvement in the disease's iron dysregulation.
- Ineffective erythropoiesis appears to be a more significant regulator of pro-hepcidin in MDS than chronic blood transfusion therapy.
- These findings contribute to understanding iron metabolism complexities in MDS.
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