Related Experiment Video
Updated: Jun 12, 2026

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
Published on: May 16, 2025
A multitude of kinases--which are the best targets in treating rheumatoid arthritis?
Tamsin M Lindstrom1, William H Robinson
1Geriatric Research Education and Clinical Center (GRECC), MC154R, VA Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, CA 94304, USA. tlind@stanford.edu <tlind@stanford.edu>
Abstract:
Small-molecule kinase inhibitors are increasingly taking center stage in the quest for new drugs for the treatment of rheumatoid arthritis (RA). By targeting kinases, small-molecule inhibitors can exert potent anti-inflammatory and immunomodulatory effects; the success of small-molecule kinase inhibitors in the treatment of cancer has spurred efforts to identify kinases that could be targeted for the treatment of chronic inflammatory disorders, such as RA. Although many kinase inhibitors have proved efficacious in the treatment of inflammatory arthritis in animals few have been tested in RA clinical trials. This article discusses the challenges and progress in the pursuit of small-molecule kinase inhibitors for RA, including lessons learned from the failure of erstwhile frontrunner inhibitors and the promise of inhibitors making their debut on the RA stage.
Related Concept Videos
The JAK-STAT Signaling Pathway
Transducer Mechanism: Enzyme-Linked Receptors
Major types that are helpful drug targets include:
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
MAPK Signaling Cascades
Receptor Tyrosine Kinases
Amplifying Signals via Enzymatic Cascade
