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The stem cell niche in health and malignancy

Monika L Burness1, Dorothy A Sipkins

  • 1Department of Medicine, Section of Hematology/Oncology, The University of Chicago Medical Center, 5841 S. Maryland Ave., MC 2115, Chicago, 60637 IL, USA.

Seminars in Cancer Biology
|June 1, 2010
PubMed
Summary

Cancer stem cells, like somatic stem cells, reside in specialized niches that control their survival and proliferation. Targeting these cancer stem cells and their microenvironments may offer new therapeutic strategies for tumor eradication.

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