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Updated: Jun 12, 2026

Monocular Visual Deprivation and Ocular Dominance Plasticity Measurement in the Mouse Primary Visual Cortex
Published on: February 8, 2020
Relative contribution of feedforward excitatory connections to expression of ocular dominance plasticity in layer 4
Lena A Khibnik1, Kathleen K A Cho, Mark F Bear
1Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139 USA.
Abstract:
Brief monocular deprivation (MD) shifts ocular dominance (OD) in primary visual cortex by causing depression of responses to the deprived eye. Here we address the extent to which the shift is expressed by a modification of excitatory synaptic transmission. An OD shift was first induced with 3 days of MD, and then the influences of intracortical polysynaptic inhibitory and excitatory synapses were pharmacologically removed, leaving only "feedforward" thalamocortical synaptic currents. The results show that the rapid OD shift following MD is strongly expressed at the level of thalamocortical synaptic transmission.
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