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Updated: Jun 12, 2026

Tractable In Vivo Reprogramming of Tumor Cells to Type 1 Conventional Dendritic Cell-like Cells
Published on: August 1, 2025
PU.1 takes control of the dendritic cell lineage
1Department of Gene and Cell Medicine, The Tisch Cancer Institute and the Immunology Institute and Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10128, USA. miriam.merad@mssm.edu
Abstract:
Despite the importance of the cytokine receptor flt3 in dendritic cell (DC) homeostasis, little is known about its regulation during DC development. In this issue of Immunity, Carotta et al. (2010) reveal that the transcription factor PU.1 controls Flt3 expression in hematopoietic progenitors in a dose-dependent manner.
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