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A decrease in maternal plasma concentrations of sVEGFR-2 precedes the clinical diagnosis of preeclampsia
Tinnakorn Chaiworapongsa1, Roberto Romero, Adi L Tarca
1Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Detroit, MI 48201, USA. tchaiwor@med.wayne.edu
American Journal of Obstetrics and Gynecology
|June 1, 2010
Summary
Maternal plasma concentrations of soluble vascular endothelial growth factor receptor 2 (sVEGFR-2) are lower before preeclampsia diagnosis. This finding may help predict preeclampsia development in pregnant women.
Area of Science:
- Obstetrics and Gynecology
- Vascular Biology
- Biomarkers in Pregnancy
Background:
- Preeclampsia is a serious pregnancy complication.
- Early detection of preeclampsia remains a challenge.
- Soluble vascular endothelial growth factor receptor 2 (sVEGFR-2) plays a role in vascular health.
Purpose of the Study:
- To investigate changes in maternal plasma sVEGFR-2 levels before preeclampsia diagnosis.
- To determine if sVEGFR-2 can serve as a predictive biomarker for preeclampsia.
Main Methods:
- Longitudinal study comparing 160 normal pregnant women with 40 preeclampsia patients.
- Blood samples collected at 7 intervals from 6 weeks gestation to term.
- Plasma sVEGFR-2 concentrations measured using enzyme-linked immunosorbent assay (ELISA).
- Analysis employed cross-sectional and longitudinal mixed-effects models.
Main Results:
- Mothers who developed preeclampsia had significantly lower plasma sVEGFR-2 concentrations compared to normal pregnancies (P < .05).
- Lower sVEGFR-2 levels were observed 6-10 weeks prior to preeclampsia diagnosis (P < .001).
- Cross-sectional analysis showed significantly lower sVEGFR-2 from 28-31 weeks gestation in preeclampsia cases (P = .001).
Conclusions:
- Reduced maternal plasma sVEGFR-2 concentrations precede the clinical diagnosis of preeclampsia.
- sVEGFR-2 may be a valuable predictive biomarker for both term and preterm preeclampsia.
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