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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Hypofractionation in adjuvant breast radiotherapy.

Atif Khan¹, Bruce G Haffty

¹Department of Radiation Oncology, UMDNJ-RWJMS, Cancer Institute of New Jersey, 195 Little Albany St., New Brunswick, NJ 08901, USA.

Breast (Edinburgh, Scotland)

|June 1, 2010

Summary

Altered fractionation for whole breast radiation therapy shows acceptable outcomes. This review summarizes evidence on hypofractionated regimens, highlighting radiobiological principles and future research needs.

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Area of Science:

Radiation Oncology
Medical Physics

Background:

Altered fractionation for whole breast irradiation has been extensively studied.
Recent publications include updated data from landmark randomized trials.

Purpose of the Study:

To review radiobiological principles of altered fractionation schedules.
To summarize outcomes, including local control and toxicities, from major studies.
To discuss the current status and future research directions for hypofractionated radiation.

Main Methods:

Review of radiobiological principles.
Summary of outcomes from major published studies on hypofractionated regimens.

Main Results:

Clinical evidence supports acceptable outcomes with hypofractionated regimens.

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Landmark trials provide updated data on efficacy and toxicity.

Conclusions:

Hypofractionated whole breast irradiation demonstrates acceptable results.
Further research is needed to address remaining questions in hypofractionated radiation therapy.