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Updated: Jun 12, 2026
05:54
MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor
Published on: December 13, 2017
No association between essential tremor and migraine: a case-control study.
Piero Barbanti1, Giovanni Fabbrini, Cinzia Aurilia
1Headache and Pain Unit, Department of Neurological, Motor and Sensorial Sciences, IRCCS San Raffaele Pisana, Rome, Italy. piero.barbanti@sanraffaele.it
Cephalalgia : an International Journal of Headache
|June 1, 2010
Summary
Essential tremor (ET) and migraine headache are not comorbid. This study found no increased frequency of migraine in ET patients compared to controls, suggesting no direct association between these conditions.
Area of Science:
- Neurology
- Clinical Neuroscience
Background:
- Essential tremor (ET) and migraine are frequently considered comorbid neurological disorders.
- Previous research suggesting comorbidity was based on uncontrolled studies.
Purpose of the Study:
- To investigate the frequency of migraine in patients diagnosed with essential tremor.
- To determine if a comorbid association exists between essential tremor and migraine.
Main Methods:
- A case-control study was conducted with 110 patients diagnosed with essential tremor.
- 110 age- and sex-matched healthy individuals served as controls.
- Migraine frequency was assessed in both groups, including stratified age analysis.
Main Results:
- No significant differences in lifetime or current migraine frequency were observed between essential tremor patients and healthy controls.
- Clinical features of tremor and migraine remained similar in patients with ET and migraine compared to controls.
- A predominance of females was noted in the subgroup of ET patients who also had migraine.
Conclusions:
- The study provides evidence against a comorbid association between essential tremor and migraine.
- The coexistence of ET and migraine does not appear to alter the clinical characteristics or progression of either condition.
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