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Related Concept Videos

Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Synthetic Biology02:55

Synthetic Biology

Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...

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Related Experiment Video

Updated: Jun 12, 2026

A Web-Based Workflow for Selecting Gene- and Tissue-Specific Enhancers
08:12

A Web-Based Workflow for Selecting Gene- and Tissue-Specific Enhancers

Published on: July 18, 2025

geWorkbench: an open source platform for integrative genomics.

Aris Floratos1, Kenneth Smith, Zhou Ji

  • 1Center for Computational Biology and Bioinformatics, Columbia University, 1130 St. Nicholas Ave, New York, NY 10032, USA. geworkbench@c2b2.columbia.edu

Bioinformatics (Oxford, England)
|June 1, 2010
PubMed
Summary
This summary is machine-generated.

geWorkbench is an open-source Java application offering integrated tools for genomics data analysis and visualization. It supports diverse analyses, including network reverse engineering and protein structure prediction, accessible via plug-in modules.

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Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
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Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

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Last Updated: Jun 12, 2026

A Web-Based Workflow for Selecting Gene- and Tissue-Specific Enhancers
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Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
08:03

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Published on: December 7, 2021

Area of Science:

  • Bioinformatics
  • Computational Biology
  • Genomics

Background:

  • geWorkbench is an open-source Java desktop application.
  • It integrates tools for analyzing diverse genomics data.

Purpose of the Study:

  • To provide researchers with a comprehensive platform for genomics data analysis and visualization.
  • To enable seamless access to remote data, annotation, and computational servers.

Main Methods:

  • Utilizes an open-source Java desktop application architecture.
  • Employs a plug-in module system with over 70 distinct modules.
  • Leverages standards-based middleware for data access.

Main Results:

  • Provides access to integrated tools for gene expression, sequence, protein structure, and systems biology data.
  • Offers classical analyses (clustering, classification, homology detection) and advanced algorithms.
  • Enables researchers to benefit from public infrastructure with limited local resources.

Conclusions:

  • geWorkbench is a versatile, open-source platform for advanced genomics research.
  • Its modular design and standards-based approach facilitate data analysis and collaboration.
  • It empowers researchers by providing access to sophisticated computational tools and public resources.