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Related Concept Videos

Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...

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MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent
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Elevated tumour marker: an indication for imaging?

Colm J McMahon1, Vivion Crowley, Nuala McCarroll

  • 1Department of Diagnostic Imaging, St James Hospital, Dublin 8, Ireland. colmjmcmahon@yahoo.co.uk

Annals of Clinical Biochemistry
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PubMed
Summary
This summary is machine-generated.

Elevated tumor markers without a cancer diagnosis do not warrant imaging. This study found no diagnostic value in imaging for unexplained elevated tumor markers, suggesting it should not be an independent indication for investigation.

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Area of Science:

  • Oncology
  • Medical Imaging
  • Clinical Diagnostics

Background:

  • Tumor markers are often used in cancer diagnosis and monitoring.
  • However, their utility can be limited when not validated as primary diagnostic tests or in patients without a prior cancer history.
  • Elevated tumor markers can lead to further investigations, including imaging, even without other clinical indications.

Purpose of the Study:

  • To evaluate the diagnostic utility of imaging examinations in patients presenting with elevated tumor markers.
  • To determine if imaging is beneficial when tumor markers are not primary diagnostic tools, and the patient has no cancer history or other imaging indications.

Main Methods:

  • A retrospective review of medical records was conducted over one year.
  • Included patients had abnormal carcinoembryonic antigen (CEA), CA19-9, CA125, and/or CA15-3 serology without a known cancer diagnosis.
  • Assessed the number and outcomes of imaging studies performed solely due to elevated tumor markers without other clinical indications.

Main Results:

  • 819 patients were included; 25 underwent imaging for elevated tumor markers.
  • These 25 patients underwent 29 imaging studies and had 42 elevated tumor marker tests.
  • No imaging study diagnosed a malignancy or explained the elevated tumor marker levels.

Conclusions:

  • Non-judicious use of tumor markers can lead to unnecessary imaging investigations.
  • Imaging performed solely for elevated tumor markers, without a known malignancy, yielded no positive diagnostic results in this study.
  • Elevated tumor markers should not be considered an independent indication for imaging in the absence of a known underlying malignancy.