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Updated: Jun 12, 2026

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
Published on: February 28, 2019
Radiation-induced olfactory neuroblastoma: a new etiology is possible
Veronica Perez Garcia1, Maria de los Angeles Martinez Izquierdo
1Oral and Maxillofacial Surgery Service, Gregorio Maranon Hospital, Complutense University, Madrid, Spain. veronipg@gmail.com
Purpose:
Radiation-induced olfactory neuroblastoma (ONB) is an uncommon neoplasm that is generally associated with a poor prognosis. We describe a new case of olfactory neuroblastoma in a patient previously treated for astrocytoma with holocranial radiotherapy 9 years ago.
Materials And Methods:
We reviewed the medical records of four patients with radiation-induced olfactory neuroblastoma between 2001 and 2009.
Results:
This work supports the idea that ONB can be induced by radiation.
Conclusions:
As radiotherapy is a standard treatment in other tumors, clinicians must be aware of the possibility of a second tumor induced by radiation.
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