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Related Concept Videos

Pharmacovigilance01:19

Pharmacovigilance

Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
Drug Toxicity: Risk factors01:24

Drug Toxicity: Risk factors

Adverse Drug Reactions (ADRs) are potential complications that arise during pharmacotherapy, influenced by multiple risk factors. Age plays a significant role; both neonates and the elderly are at heightened risk due to their respective immature and diminished metabolic and elimination processes. Gender also impacts ADRs, with females experiencing a 1.5 to 1.7-fold greater risk than males, which may be linked to pharmacokinetic, pharmacodynamic, and hormonal differences. Notably, neonates, the...
Drug Toxicity: Overview01:00

Drug Toxicity: Overview

Drug toxicity quantifies the harm a compound causes to an organism, varying by dose and potentially impacting whole systems or specific organs like the liver. Toxic reactions may arise from venomous insect or spider bites, with effects ranging from mild symptoms to severe outcomes such as brain damage or death. Common forms of acute poisoning include ethanol intoxication and overdose of pain or fever medications, with substances like GHB and heroin being particularly lethal at doses close to...
Drug toxicity: Drug–Drug Interaction01:30

Drug toxicity: Drug–Drug Interaction

Drug–drug interactions can precipitate toxicity through multiple mechanisms. Absorption interactions alter how drugs enter the body, exemplified when ranitidine increases the absorption of basic drugs, while cholestyramine decreases the levels of propranolol. Protein binding interactions occur when drugs share the same binding sites on plasma proteins. Drugs like aspirin and warfarin, when bound in excess, can lead to increased free drug concentrations, enhancing the potential for...
Pharmaceutical Poisoning: Potential Scenarios01:26

Pharmaceutical Poisoning: Potential Scenarios

Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...
Obedience01:08

Obedience

According to obedience research, we may harm others under the forceful pressures of an authority figure (Milgram, 1974). How about if the inappropriate orders were delivered with less force? The increasing interdependence between nurses and physicians compelled Hofling and his colleagues to explore nurses’ reactions to a potentially harmful medical request made by the perceived authority figure, the doctor (Hofling, Brotzman, Dalrymple, Graves, & Pierce, 1966). In this situation, obedience...

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Related Experiment Video

Updated: Jun 12, 2026

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
07:13

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

[Adverse reactions and risks associated with non compliance].

Stefan Russmann1, Ivanka Curkovic, Martin Huber

  • 1Klinik für Klinische Pharmakologie und Toxikologie, Universitätsspital Zürich. stefan.russmann@usz.ch

Therapeutische Umschau. Revue Therapeutique
|June 1, 2010
PubMed
Summary

Patient non-compliance in clinical practice poses risks and costs. Strategies for prevention, including improved communication and technology, are crucial for effective pharmacotherapy and patient safety.

Related Experiment Videos

Last Updated: Jun 12, 2026

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
07:13

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

Area of Science:

  • Clinical Pharmacy
  • Health Services Research
  • Patient Adherence Studies

Context:

  • Non-compliance is a common issue in healthcare settings.
  • It leads to significant risks, adverse reactions, and increased costs.
  • Forms include incorrect dosing, timing, early/late termination, and unmanaged drug interactions.

Purpose:

  • To highlight the multifaceted nature of non-compliance.
  • To present risks and adverse effects associated with non-compliance.
  • To discuss preventative strategies and the role of healthcare providers and systems.

Summary:

  • Non-compliance encompasses various deviations from prescribed treatments, such as missed doses, wrong dosages, or self-medication.
  • These behaviors can result in reduced treatment efficacy, adverse events, and higher healthcare expenditures.
  • Effective prevention requires addressing pharmacotherapy, patient factors, and the healthcare system, emphasizing trust and communication.

Impact:

  • Improved patient adherence can lead to better therapeutic outcomes and reduced healthcare costs.
  • Understanding non-compliance mechanisms aids in developing targeted interventions.
  • Future prevention may be enhanced by health information technology like computerized physician order entry and clinical decision support systems.