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Steroid therapy and duodenal ulcer in infants
Y G Wolf1, T Reyna, K P Schropp
1Department of Pediatric Surgery, Children's Hospital, Columbus, Ohio.
Journal of Pediatric Gastroenterology and Nutrition
|February 1, 1991
Insights
Steroid therapy in infants can lead to serious duodenal ulcers. This study highlights the critical need for preventative ulcer medication, or prophylaxis, in infants receiving steroids to avoid severe complications.
Area of Science:
- Pediatrics
- Gastroenterology
- Pharmacology
Background:
- Steroid administration is associated with an increased risk of peptic ulcer disease.
- The necessity of prophylactic ulcer treatment in infants undergoing steroid therapy remains a debated topic in clinical practice.
Abstract:
Two infants with acute life-threatening complications of duodenal ulcer following steroid administration are described. Although the possible association between steroid therapy and peptic ulcer disease is well known, the need for ulcer prophylaxis during such therapy in infants is not unanimously accepted. The case for ulcer prophylaxis in this setting is presented.