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Hypereosinophilic syndrome in childhood appearing as inflammatory bowel disease
A G Falade1, P J Darbyshire, F Raafat
1Institute of Child Health, University of Birmingham, England.
Insights
This is the first reported case of a child with hypereosinophilic syndrome (HES) who developed inflammatory bowel disease (IBD). Steroid therapy provided a positive clinical and hematological response.
Area of Science:
- Pediatric Gastroenterology
- Hematology
- Immunology
Background:
- Hypereosinophilic syndrome (HES) is a rare disorder characterized by persistent eosinophilia.
- Inflammatory bowel disease (IBD) encompasses chronic inflammatory conditions of the gastrointestinal tract.
Observation:
- A 7-year-old girl presented with HES, hepatosplenomegaly, anemia, and hypergammaglobulinemia.
- Colonoscopy revealed nonspecific colitis.
Findings:
- The patient experienced a prompt clinical and partial hematological improvement with systemic steroid treatment.
- An elemental diet was ineffective in managing the condition.
Implications:
- This case highlights a potential association between HES and IBD in pediatric patients.
- Systemic steroids may be an effective treatment option for HES-associated IBD.
- Further research is needed to understand the underlying mechanisms connecting HES and IBD.
Abstract:
A 7-year-old girl with hypereosinophilic syndrome is described, the first such patient to present with inflammatory bowel disease. Hepatosplenomegaly, anaemia, and hypergammaglobulinaemia were also prominent features. Colonoscopy revealed a frank colitis of nonspecific histologic appearance. An elemental diet was unhelpful, but there was a prompt clinical and partial haematological response to systemic steroids. She has remained well receiving a small maintenance dose of prednisolone for 3 years.