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Related Experiment Video

Updated: Jun 12, 2026

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis

Published on: June 2, 2015

Ambulation after deep vein thrombosis: a systematic review.

Cathy M Anderson¹, Tom J Overend, Julie Godwin

¹Cathy M. Anderson, BHSc PT, MSc: Clinical Specialist, Physiotherapy, London Health Sciences Centre, London, Ontario.

Physiotherapy Canada. Physiotherapie Canada

|June 2, 2010

Summary

Early ambulation for deep vein thrombosis (DVT) patients does not increase the risk of pulmonary embolism (PE) or thrombus progression. Clinicians can confidently prescribe early mobility for DVT patients.

Keywords:

acute deep vein thrombosis ambulation pulmonary embolism venous thrombosis walking

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Last Updated: Jun 12, 2026

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis

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Point-Of-Care Ultrasound Screening for Proximal Lower Extremity Deep Venous Thrombosis

Point-Of-Care Ultrasound Screening for Proximal Lower Extremity Deep Venous Thrombosis

Published on: February 10, 2023

Area of Science:

Cardiology
Vascular Medicine
Clinical Research

Background:

Deep vein thrombosis (DVT) is a serious condition often requiring prolonged immobility.
The development of pulmonary embolism (PE) and thrombus progression are significant risks associated with DVT.
Early ambulation is a potential intervention to mitigate these risks, but its safety and efficacy require systematic evaluation.

Purpose of the Study:

To systematically review the effects of early ambulation on the incidence of pulmonary embolism (PE).
To assess the impact of early ambulation on the progression or development of new thrombi in patients diagnosed with acute deep vein thrombosis (DVT).

Main Methods:

A comprehensive literature search was conducted across major databases (Medline, PubMed, CINAHL, EMBASE, PEDro, Cochrane Library) up to June 2008.
Study quality was rigorously appraised using the Jadad and PEDro scales.
Meta-analyses were performed, reporting findings as relative risks (RR) with 95% confidence intervals (CI).

Main Results:

Four randomized controlled trials met the inclusion criteria.
Ambulation did not significantly increase the risk of developing PE compared to bed rest (RR = 0.63, 95% CI: 0.34-1.19; RR = 1.36, 95% CI: 0.57-3.29).
There was no significant difference in the progression or development of new thrombi between ambulation and bed rest groups (RR = 0.39, 95% CI: 0.13-1.14; RR = 0.56, 95% CI: 0.20-1.57).

Conclusions:

The study found no significant increase in the risk of PE or thrombus progression with early ambulation in DVT patients.
Given the established clinical benefits of mobility, clinicians can be confident in prescribing early ambulation for patients with acute DVT.
Early ambulation is a safe and potentially beneficial strategy for managing acute deep vein thrombosis.