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A Protocol for Analyzing Hepatitis C Virus Replication
13:04

A Protocol for Analyzing Hepatitis C Virus Replication

Published on: June 26, 2014

[HIV and hepatitis C co-infection]

M Vogel1, C Boesecke, J-C Wasmuth

  • 1Medizinische Klinik und Poliklinik I, Universitätsklinikum Bonn.

Deutsche Medizinische Wochenschrift (1946)
|June 2, 2010
PubMed

Insights

HIV and Hepatitis C Virus (HCV) co-infection accelerates liver disease progression. Early HAART initiation and HCV treatment are recommended for co-infected patients to slow fibrosis and prevent complications.

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Immunology

Background:

  • Chronic hepatitis C virus (HCV) infection is a major comorbidity in HIV-infected individuals, affecting one-third in Europe.
  • HIV/HCV co-infection accelerates liver cirrhosis, decompensation, and hepatocellular carcinoma compared to HCV mono-infection, especially with severe immunodeficiency.

Purpose of the Study:

  • To review the epidemiology and natural course of HCV in HIV co-infection.
  • To summarize current guidelines for managing chronic hepatitis C in HIV co-infected patients.

Main Methods:

  • Literature review of epidemiological data.
  • Analysis of the natural history of HCV in the context of HIV.
  • Synthesis of current clinical management guidelines.

Main Results:

  • Immune reconstitution with HAART slows liver fibrosis progression in HIV/HCV co-infected individuals.
  • HCV treatment with pegylated interferon and ribavirin can halt disease sequelae.

Conclusions:

  • Early HAART initiation is advised for HCV co-infected patients.
  • All HIV/HCV co-infected patients should be evaluated for HCV treatment eligibility.

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