Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Lymphoid Cells and Tissues

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...

Primary Lymphoid Organs

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...

Secondary Lymphoid Organs

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Functional recovery effects of growth factor-stimulated mesenchymal stromal cells in a Wistar rat model of ankle sprain injury.

International orthopaedics·2026

Same author

Baseline CD4<sup>+</sup>/CD8<sup>+</sup> T<sub>EMRA</sub> Levels and Early Response Predict Survival After Umbilical Cord-Derived Mesenchymal Stem Cells Infusion in Acute GVHD Patients: A Randomized Double-Blinded Placebo-Controlled Multicentre Clinical Trial.

Journal of blood medicine·2025

Same author

Effects of house-cultivated edible bird's nest on immunoglobulin and cytokine release <i>in vitro</i>.

Veterinary world·2024

Same author

Revealing the potential role of hsa-miR-663a in modulating the PI3K-Akt signaling pathway via miRNA microarray in spinal muscular atrophy patient fibroblast-derived iPSCs.

Journal of neuropathology and experimental neurology·2024

Same author

Dynamic tracking of human umbilical cord mesenchymal stem cells (hUC-MSCs) following intravenous administration in mice model.

Regenerative therapy·2024

Same author

Effect of six-week short-duration deep breathing on young adults with chronic ankle instability-a pilot randomized control trial.

BMC sports science, medicine & rehabilitation·2023

Search research articles

Related Experiment Video

Updated: Jun 12, 2026

Generation and Labeling of Murine Bone Marrow-derived Dendritic Cells with Qdot Nanocrystals for Tracking Studies

Generation and Labeling of Murine Bone Marrow-derived Dendritic Cells with Qdot Nanocrystals for Tracking Studies

Published on: June 2, 2011

Dendritic cell distribution in lymphomas.

Hamidah Noor Hussin¹, Fadzilah Noor Zulkifli, Koon Song Phang

¹Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur.

The Malaysian Journal of Pathology

|June 3, 2010

Summary

This study found significantly fewer dendritic cells (DC), crucial for anti-tumour immunity, in lymphoma tissues compared to inflammatory conditions. Both mature and immature DC were reduced, impacting immune surveillance.

More Related Videos

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Isolation Protocol of Mouse Monocyte-derived Dendritic Cells and Their Subsequent In Vitro Activation with Tumor Immune Complexes

Isolation Protocol of Mouse Monocyte-derived Dendritic Cells and Their Subsequent In Vitro Activation with Tumor Immune Complexes

Published on: May 31, 2018

Related Experiment Videos

Last Updated: Jun 12, 2026

Generation and Labeling of Murine Bone Marrow-derived Dendritic Cells with Qdot Nanocrystals for Tracking Studies

Generation and Labeling of Murine Bone Marrow-derived Dendritic Cells with Qdot Nanocrystals for Tracking Studies

Published on: June 2, 2011

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Isolation Protocol of Mouse Monocyte-derived Dendritic Cells and Their Subsequent In Vitro Activation with Tumor Immune Complexes

Isolation Protocol of Mouse Monocyte-derived Dendritic Cells and Their Subsequent In Vitro Activation with Tumor Immune Complexes

Published on: May 31, 2018

Area of Science:

Immunology
Oncology
Pathology

Background:

Dendritic cells (DC) are vital antigen-presenting cells (APC) in host defense and anti-tumour immunity.
Abnormalities in DC frequency and maturation are observed in malignant tumors.

Purpose of the Study:

To investigate the distribution and maturation status of dendritic cells in lymphoma tissues.
To compare DC characteristics in lymphoma versus inflammatory conditions.

Main Methods:

Immunohistochemistry was used to analyze formalin-fixed, paraffin-embedded lymph node tissues.
The study included 32 cases of histologically diagnosed lymphomas and 40 inflammatory conditions.

Main Results:

Lymphoma tissues exhibited a significant reduction in total dendritic cell counts compared to inflammatory conditions.
Both mature and immature DC counts were significantly decreased in lymphomas, with a more pronounced reduction in mature DC.
Immature DC were found within tumor tissues, while mature DC were predominantly located in peri-tumoral areas.

Conclusions:

Reduced numbers of dendritic cells, particularly mature ones, may impair anti-tumour immune surveillance in lymphoma.
The observed compartmentalization of DC suggests altered immune microenvironments in lymphoma.