Related Experiment Video
Updated: Jun 12, 2026

Modifying Levels of Maternal Dietary Folic Acid or Choline to Study the Impact of Deficiencies on Offspring Health Outcomes
Published on: June 28, 2024
Effect of in-home fortification of complementary feeding on intellectual development of Chinese children
Chun-Ming Chen1, Yu-Ying Wang, Su-Ying Chang
1Chinese Center for Disease Control and Prevention, Beijing 100050, China. chencm@ilsichina.org
Insights
In-home fortification of complementary foods significantly improved intellectual development in young Chinese children. This nutritional intervention showed lasting effects on cognitive scores, highlighting its importance for early childhood development.
Area of Science:
- Pediatric Nutrition
- Developmental Psychology
- Public Health
Background:
- Early childhood is a critical period for intellectual development.
- Complementary feeding plays a vital role in providing essential nutrients.
- Nutritional deficiencies can negatively impact cognitive outcomes.
Purpose of the Study:
- To investigate the impact of in-home complementary food fortification on intellectual development.
- To assess the effects in Chinese children under 24 months of age.
Main Methods:
- A study involving 1,478 children aged 4-12 months, divided into two fortified formula groups and a control group.
- Fortified food supplements were administered daily to study groups.
- Developmental Quotient (DQ) and Intelligence Quotient (IQ) were assessed, alongside physical growth and hemoglobin levels.
Main Results:
- Children in both fortified groups showed significantly higher DQ scores compared to the control group at all follow-up points.
- Formula 1 group (protein and micronutrients) demonstrated statistically significant higher Full-IQ, Verbal IQ, and Performance IQ scores.
- The positive effects on intellectual development were observed to be persistent.
Conclusions:
- In-home fortification of complementary feeding has a lasting positive effect on children's intelligence.
- Intervention during the critical period, potentially before 18 months, is crucial for cognitive development and anemia correction.
Objective:
To explore the effect of in-home fortification of complementary feeding on intellectual development of Chinese children aged below 24 months.
Methods:
One thousand and four hundred seventy eight children aged 4-12 months were recruited and divided into study groups (formula 1 group and formula 2 group) and control group. In two study groups, in addition to the usual complementary food, children were fed with a sachet of fortified food supplement each day. Protein and micronutrients were provided in formula 1 group. Formula 2 group had the same energy intake as the formula 1 group . In addition to measurement of physical growth and detection of hemoglobin level, Development Quotient (DQ) or Intelligence Quotient (IQ) was assessed.
Results:
The DQ of children aged below 24 months was 97.2, 95.5, and 93.8 in formula 1 group, formula 2 group and control group, respectively, and the differences were statistically significant (P < 0.05). The DQ of children in formula 1 group, formula 2 group, and control group was 92.7, 90.4, and 88.3 respectively in the first follow up showing statistically significant differences (P < 0.05). And, DQ of children in formula 1 group, formula 2 group and control group were 96.7, 94.5, and 93.7 respectively in the second follow up, showing statistically significant differences (P < 0.05). Full-IQ of children in the formula 1 group was 3.1 and 4.5 points higher than that in formula 2 group and in control group respectively. Verbal IQ of children in the formula 1 group was 2.1 and 5 points higher than that in formula 2 group and control group respectively. Performance IQ was 2.5 and 3.1 points higher than that in formula 2 group and control group respectively. All above mentioned comparisons were statistically significant.
Conclusion:
Fortification of complementary feeding showed persistent effect on intelligence development of young children which could persist to 6 years of age. The critical time for correction of anemia could be under 18 months.
Related Concept Videos
Environmental Influences on Intelligence
Biological Influences on Intelligence
Nature and Nurture
Information Processing Approach
Intellectual Disability
Binet's Contribution to Measures of Intelligence