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Published on: June 10, 2021
Light-induced isomerization of apoptolidin a leads to inversion of C2-C3 double bond geometry
Brian O Bachmann1, Ruth McNees, Bruce J Melancon
1Department of Chemistry, Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 77842-3012, USA. brian.bachmann@vanderbilt.edu
Abstract:
The isolation, characterization, and cytotoxicity against H292 cells of apoptolidin G are reported. Apoptolidin G is shown to be derived by a light-induced isomerization of the C2-C3 carbon-carbon double bond of apoptolidin A.
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