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Duplex Doppler sonography in renal parenchymal disease. Histopathologic correlation
G H Mostbeck1, R Kain, R Mallek
1Division of Radiology, University of Vienna Hospital, Austria.
Summary
Doppler ultrasound resistive index (RI) measurements in renal arteries correlate with histopathologic changes in renal parenchymal diseases. However, RI does not reliably differentiate between various kidney disease types.
Area of Science:
- Nephrology
- Radiology
- Pathology
Background:
- Renal parenchymal diseases can affect renal artery Doppler measurements.
- The resistive index (RI) is a key parameter in assessing renal vascular resistance.
Purpose of the Study:
- To correlate histopathologic changes in renal parenchymal diseases with Doppler measurements of the resistive index (RI).
- To evaluate the utility of RI in differentiating various renal medical disorders.
Main Methods:
- Duplex Doppler ultrasound (US) was performed on 68 kidneys in 34 patients before percutaneous renal biopsy.
- RI, renal length, and cortical echogenicity were correlated with graded histopathologic findings (glomerular, interstitial, vascular changes).
Main Results:
- RI significantly correlated with arteriolosclerosis, glomerular sclerosis, arteriosclerosis, edema, and focal interstitial fibrosis.
- No significant difference in RI was observed across five groups of renal parenchymal diseases.
- RI increased with patient age, linked to arteriosclerosis prevalence.
- Quantitative duplex US using RI did not reliably distinguish between different renal medical disorders.
Conclusions:
- While RI reflects underlying histopathologic changes in renal diseases, it lacks specificity for differentiating disease types.
- Age-related arteriosclerosis influences RI, potentially confounding interpretation in older patients.