Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Insulin: Dosing Regimen and Adverse Effects01:16

Insulin: Dosing Regimen and Adverse Effects

Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
Insulin Formulations: Types and Delivery01:27

Insulin Formulations: Types and Delivery

Insulin preparations are categorized by their duration of action into short-acting and long-acting types. Two strategies are used to modify insulin's absorption and pharmacokinetic profile: slowing the absorption post-subcutaneous injection, or altering human insulin's amino acid sequence or protein structure. These changes retain the insulin's ability to bind to the insulin receptor, but alter its behavior in solution or after injection.
Short-acting insulins are divided into rapid-acting...
Insulin: Biosynthesis, Chemistry, and Preparation01:25

Insulin: Biosynthesis, Chemistry, and Preparation

The endoplasmic reticulum (ER) of pancreatic β-cells synthesizes preproinsulin, which consists of a signal peptide, A and B chains, and a C-peptide. Preproinsulin is then cleaved and folded into proinsulin, which translocates to the Golgi apparatus for sorting and packaging into secretory granules. In these granules, enzymatic clipping generates insulin and C-peptide.
Damage or functional impairment of β-cells inhibits insulin production, leading to diabetes. Diabetes treatment primarily uses...
Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Glucose Homeostasis: Pancreatic Islets and Insulin Secretion01:27

Glucose Homeostasis: Pancreatic Islets and Insulin Secretion

The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
Insulin and C-peptide are co-secreted in...
Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices01:28

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prospective Cohort Study Evaluating Impact of Hemodialysis on Glycemia: BLOSSOM (Blood Sugar Sensing on Maintenance Dialysis) Cohort Findings.

Clinical journal of the American Society of Nephrology : CJASN·2026
Same author

The Use of Prophylactic Insulin in Surgical Patients without Diabetes: A Pilot Randomized, Controlled Trial.

Annals of surgery·2026
Same author

Corrigendum to "American Association of Clinical Endocrinology Consensus Statement: Algorithm for Management of Adults With Type 2 Diabetes - 2026 Update" [Endocrine Practice. 2026;32(4):473-518].

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·2026
Same author

Adjunctive Treatment with GLP-1 and Dual GLP-1/GIP Receptor Agonists for People with Type 1 Diabetes: Consensus Report and Practical Guidelines for Safe Use.

Diabetes technology & therapeutics·2026
Same author

Letter: Treatment of Type 2 Diabetes in the United States: 2025.

Diabetes technology & therapeutics·2026
Same author

Glycemic Trends From Continuous Glucose Monitoring With DPP-4 Inhibitor Therapy in Patients With Type 2 Diabetes-Redefining the Role of an Overlooked Agent.

Diabetes care·2026

Related Experiment Video

Updated: Jun 12, 2026

Improving IV Insulin Administration in a Community Hospital
12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

Practical pearls in insulin pump therapy.

Irl B Hirsch1

  • 1University of Washington School of Medicine, Medical Center, 4225 Roosevelt Way NE, Seattle, WA 98101, USA. ihirsch@u.washington.edu

Diabetes Technology & Therapeutics
|June 3, 2010
PubMed
Summary
This summary is machine-generated.

Continuous subcutaneous insulin infusion (CSII) therapy can be optimized with practical strategies. Key improvements in diabetes management involve patient selection, data interpretation, and leveraging technology for better glycemic control.

Related Experiment Videos

Last Updated: Jun 12, 2026

Improving IV Insulin Administration in a Community Hospital
12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

Area of Science:

  • Endocrinology
  • Metabolic Diseases
  • Diabetes Management

Background:

  • Continuous subcutaneous insulin infusion (CSII) therapy is often guided by anecdotal evidence and trial-and-error.
  • There is a need for evidence-based practical guidelines to enhance CSII effectiveness.

Purpose of the Study:

  • To review and present practical strategies ('pearls') for optimizing continuous subcutaneous insulin infusion (CSII) therapy.
  • To identify key factors that can lead to improved diabetes control outcomes in patients using CSII.

Main Methods:

  • This study is a review of existing practices and literature concerning CSII.
  • It synthesizes practical recommendations based on clinical experience and case reports.

Main Results:

  • Eight practical pearls for effective CSII management were identified.
  • These include efficient clinic systems, appropriate patient selection, understanding blood glucose data, matching insulin to food intake, and utilizing advanced technologies like bolus calculators.

Conclusions:

  • Implementing these practical pearls can significantly improve diabetes management for patients on CSII.
  • Optimizing CSII involves a multifaceted approach encompassing patient factors, data utilization, and technological integration for enhanced glycemic control.