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Related Concept Videos

Insulin Formulations: Types and Delivery01:27

Insulin Formulations: Types and Delivery

Insulin preparations are categorized by their duration of action into short-acting and long-acting types. Two strategies are used to modify insulin's absorption and pharmacokinetic profile: slowing the absorption post-subcutaneous injection, or altering human insulin's amino acid sequence or protein structure. These changes retain the insulin's ability to bind to the insulin receptor, but alter its behavior in solution or after injection.
Short-acting insulins are divided into rapid-acting...
Insulin: Dosing Regimen and Adverse Effects01:16

Insulin: Dosing Regimen and Adverse Effects

Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices01:28

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...
One-Compartment Open Model for IV Bolus Administration: General Considerations01:19

One-Compartment Open Model for IV Bolus Administration: General Considerations

The one-compartment model is a pharmacokinetic tool that models the body as a single, uniform compartment, facilitating the understanding of drug distribution and elimination. This model is particularly beneficial for intravenous (IV) bolus administration, where the drug rapidly circulates throughout the body.
The drug's presence in the body is defined by an equation representing the difference between the rates of drug entry and exit. Key parameters—elimination rate constant, half-life,...
Insulin: Biosynthesis, Chemistry, and Preparation01:25

Insulin: Biosynthesis, Chemistry, and Preparation

The endoplasmic reticulum (ER) of pancreatic β-cells synthesizes preproinsulin, which consists of a signal peptide, A and B chains, and a C-peptide. Preproinsulin is then cleaved and folded into proinsulin, which translocates to the Golgi apparatus for sorting and packaging into secretory granules. In these granules, enzymatic clipping generates insulin and C-peptide.
Damage or functional impairment of β-cells inhibits insulin production, leading to diabetes. Diabetes treatment primarily uses...
Oral Hypoglycemic Agents: Glinides01:06

Oral Hypoglycemic Agents: Glinides

Repaglinide (Prandin) and Nateglinide (Starlix), known as glinides, are oral insulin secretagogues that stimulate insulin release from pancreatic β cells by closing the ATP-sensitive potassium channels (KATP channel). Repaglinide controls insulin release from pancreatic β cells by managing potassium efflux. It shares two binding sites with sulfonylureas and also has a unique site, indicating overlapping mechanisms of action. With a rapid onset and a 4-7 hour duration, it effectively manages...

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Updated: Jun 12, 2026

Improving IV Insulin Administration in a Community Hospital
12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

Considerations in insulin delivery device selection.

Virginia Valentine1, Davida F Kruger

  • 1Diabetes Network Inc. 4108 Alcazar N.E., Albuquerque, NM 87109, USA. vv@diabetestalk.com

Diabetes Technology & Therapeutics
|June 3, 2010
PubMed
Summary
This summary is machine-generated.

Insulin pens offer benefits for type 2 diabetes management, improving adherence and glucose control. Understanding device features is key for healthcare professionals to optimize patient success with insulin therapy.

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Area of Science:

  • Endocrinology
  • Pharmacology
  • Medical Devices

Background:

  • Current guidelines recommend earlier insulin initiation for type 2 diabetes (T2D) to achieve glycemic control (<7%).
  • Despite expert consensus, achieving tight glucose control with insulin remains challenging for many T2D patients.
  • Existing guidelines lack specific recommendations for insulin delivery systems.

Purpose of the Study:

  • To highlight the benefits of insulin pen delivery devices for T2D management.
  • To emphasize the importance of understanding device features for optimal patient outcomes.
  • To provide considerations for selecting appropriate insulin delivery devices.

Main Methods:

  • Review of current guidelines and expert consensus on T2D insulin therapy.
  • Analysis of features and benefits associated with insulin pen delivery devices.
  • Discussion of factors influencing patient adherence and acceptance of insulin delivery systems.

Main Results:

  • Insulin pens offer advantages such as accurate dosing and ease of use.
  • Patient acceptance and adherence are positively impacted by user-friendly insulin delivery devices.
  • Understanding device specifics is crucial for healthcare providers to guide patient selection.

Conclusions:

  • Optimizing insulin delivery device selection can enhance patient success in achieving glycemic targets.
  • Healthcare professionals need comprehensive knowledge of insulin pens to effectively guide T2D patients.
  • Improved device selection can contribute to better overall management of type 2 diabetes.