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Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
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Related Experiment Video

Updated: Jun 12, 2026

Mimicking and Measuring Occlusal Erosive Tooth Wear with the "Rub&Roll" and Non-contact Profilometry
08:47

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Published on: February 2, 2018

Bruxism after 3,4-methylenedioxymethamphetamine (ecstasy) abuse.

Ricardo Jorge Dinis-Oliveira1, Inês Caldas, Félix Carvalho

  • 1Faculty of Medicine, Institute of Legal Medicine, University of Porto, Porto, Portugal. ricardinis@sapo.pt

Clinical Toxicology (Philadelphia, Pa.)
|June 3, 2010
PubMed
Summary

Drug-induced bruxism is a known issue. This report details bruxism linked to 3,4-methylenedioxymethamphetamine (MDMA), commonly known as ecstasy, in three patients.

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Clinical Medicine

Background:

  • Bruxism, the involuntary grinding or clenching of teeth, is a recognized adverse effect associated with various pharmaceutical and recreational substances.
  • Understanding the link between substance abuse and neurological side effects is crucial for patient care and public health.

Purpose of the Study:

  • To present clinical cases illustrating the association between 3,4-methylenedioxymethamphetamine (MDMA) abuse and the manifestation of bruxism.
  • To highlight MDMA as a potential cause of drug-induced bruxism.

Main Methods:

  • Case report methodology.
  • Clinical observation and patient history documentation of individuals with a history of MDMA abuse presenting with bruxism.

Main Results:

  • Three patients abusing MDMA presented with symptoms of bruxism.
  • The bruxism symptoms were temporally associated with their reported MDMA use.

Conclusions:

  • 3,4-methylenedioxymethamphetamine (MDMA) abuse can induce or exacerbate bruxism.
  • Clinicians should consider MDMA as a potential causative agent in patients presenting with unexplained bruxism.