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Published on: February 26, 2013

Uric acid elevation in atrial fibrillation.

Konstantinos P Letsas1, Panagiotis Korantzopoulos, Gerasimos S Filippatos

  • 1Second Department of Cardiology, Evangelismos General Hospital of Athens, Greece.

Hellenic Journal of Cardiology : HJC = Hellenike Kardiologike Epitheorese
|June 3, 2010
PubMed
Summary
This summary is machine-generated.

Elevated uric acid levels are associated with permanent atrial fibrillation (AF). While C-reactive protein is an independent predictor of AF, uric acid also predicts permanent AF, suggesting a link to disease burden.

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Published on: July 20, 2022

Area of Science:

  • Cardiology
  • Biochemistry

Background:

  • Uric acid is a known cardiovascular risk marker linked to oxidative stress and inflammation.
  • Atrial fibrillation (AF) is increasingly recognized for its association with inflammatory processes and oxidative stress.

Purpose of the Study:

  • To investigate the potential association between elevated uric acid levels and the presence of atrial fibrillation.
  • To explore the relationship between uric acid and different types of AF (paroxysmal vs. permanent).

Main Methods:

  • A study population comprising patients with paroxysmal AF, permanent AF, and healthy controls was recruited.
  • Demographic, clinical, echocardiographic data, uric acid levels, and inflammatory markers (e.g., C-reactive protein) were collected and analyzed.
  • Statistical analyses included univariate and multivariate logistic regression to identify independent predictors.

Main Results:

  • Significant differences in uric acid levels were observed across paroxysmal AF, permanent AF, and control groups (p<0.001).
  • Univariate analysis revealed associations of AF with age, hypertension, beta-blocker use, low left ventricular ejection fraction (LVEF), left atrial diameter, uric acid, and C-reactive protein (CRP).
  • Multivariate analysis identified CRP as an independent predictor for AF. Subgroup analysis showed CRP and LVEF predicted paroxysmal AF, while CRP, uric acid, and LVEF predicted permanent AF.

Conclusions:

  • Increased uric acid levels are associated with permanent atrial fibrillation.
  • Uric acid elevation may correlate with the AF disease burden.
  • Further large-scale studies are warranted to confirm the association between uric acid and AF.