Related Experiment Video
Updated: Jun 12, 2026

Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits (Oryctolagus cuniculus)
Published on: July 31, 2021
Determinants of partial or no primary immunisations
L J Jessop1, C C Kelleher, C Murrin
1School of Public Health and Population Science, Woodview House, University College Dublin, Belfield, Dublin 4, Ireland. cecily.kelleher@ucd.ie
Insights
Maternal factors like alternative practitioner visits and lower psychological quality of life scores, along with socioeconomic status and rural location, significantly impact children
Area of Science:
- Pediatric Health
- Public Health
- Epidemiology
Background:
- Primary immunizations are crucial for child health and disease prevention.
- Understanding factors influencing immunization uptake is vital for public health strategies.
- Previous research has identified various socioeconomic and demographic predictors of vaccination status.
Purpose of the Study:
- To investigate factors associated with full, partial, or no primary immunizations in children.
- To identify specific maternal, socioeconomic, and geographical determinants of immunization coverage.
Main Methods:
- Cross-generational cohort study conducted in urban and rural Ireland (2001-2003) with 5-year follow-up.
- Linked primary care and hospital records for 749 children with immunization data.
- Statistical analysis using adjusted relative risk ratios and odds ratios.
Main Results:
- High uptake of primary immunizations (92.8% full, 4.9% partial, 2.3% none).
- No immunization significantly associated with maternal alternative practitioner visits (RR 3.69), means-tested medical services eligibility (RR 8.11), low WHO-QOL psychological score (RR 8.82), and rural western Ireland (RR 3.64).
- Premature birth was linked to partial immunization (OR 4.63).
Conclusions:
- Specific maternal characteristics, socioeconomic factors, and geographical location are significant predictors of incomplete primary immunization.
- Targeted interventions are needed to address disparities and improve full immunization uptake.
- Findings can inform public health campaigns to enhance childhood vaccination rates.
Objective:
To determine if different factors affect children having full, partial or no primary immunisations.
Methods:
This was a crossgenerational cohort study with linkage to primary care and hospital records conducted in urban and rural settings in Ireland, recruiting in 2001-2003 with 5-year follow-up. A total of 749 children with immunisation information took part.
Results:
The uptake of reported primary immunisations was 92.8% full, 4.9% partial and 2.3% no primary immunisations. Adjusted relative risk ratios for children receiving no primary immunisations were significant for: having a mother who had ever visited an alternative practitioner 3.69 (1.05 to 12.9), a mother with means tested full general medical services eligibility 8.11 (1.58 to 41.65), a mother who scored <50 for the World Health Organization Quality of Life (WHO-QOL) scale psychological domain 8.82 (1.79 to 43.6) or living in the west of Ireland (rural) 3.64 (1.0 to 13.2). Being born prematurely was associated with partial primary immunisation, adjusted OR 4.63 (1.24 to 17.3).
Conclusions:
Knowledge of these differences will help target campaigns to increase full uptake of primary immunisations.
More Related Videos
05:31Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
09:37Detection of Polyfunctional T Cells in Children Vaccinated with Japanese Encephalitis Vaccine via the Flow Cytometry Technique
Published on: September 23, 2022
Related Concept Videos
Development of Immunocompetence
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
Smallpox
Vaccinations
Immunodeficiency Diseases
There are three main causes of immunodeficiency disorders...
Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
Active versus Passive Immunity
Active Immunity
Active immunity refers to the resistance one develops...