Less invasive autopsy: an evidenced based approach.

Area of Science:

• Medical Imaging
• Pathology
• Pediatrics

Background:

• Less invasive autopsy using postmortem MRI shows promise but lacks widespread clinical acceptance.
• Current evidence is mainly focused on fetal brain malformations, limiting broader application.
• Rising autopsy rates are a potential benefit, but data accuracy and credibility are paramount.

Purpose of the Study:

• To review current evidence on less invasive autopsy via postmortem MRI.
• To discuss practical aspects and future directions for non-forensic applications in fetuses, newborns, and children.
• To highlight the need for a systematic, evidence-based approach to ensure data integrity.

Main Methods:

• Review of existing literature on postmortem MRI for less invasive autopsy.
• Analysis of prospective studies evaluating the accuracy of postmortem MRI.
• Synthesis of practical considerations for implementation in pediatric settings.

Main Results:

• Postmortem MRI is not yet a widely accepted clinical tool despite initial promise.
• Large prospective studies are nearing completion, which may provide crucial accuracy data.
• Evidence base for less invasive autopsy in fetuses, newborns, and children is still developing.

Conclusions:

• Successful implementation of less invasive autopsy requires a multidisciplinary approach involving clinicians, radiologists, pathologists, and parent groups.
• An evidence-based and systematic process is mandatory to maintain the accuracy and credibility of postmortem MRI data.
• Further research and validation are needed to integrate postmortem MRI into routine pediatric autopsy practices.