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Related Experiment Videos

[Study on cases of D dimer values were dissociated from FDP-E].

M Himizu1, K Ishii, H Katagiri

  • 1Department of Laboratory Medicine, Keio University, School of Medicine, Tokyo.

Rinsho Byori. the Japanese Journal of Clinical Pathology
|March 1, 1991
PubMed
Summary

Fibrin degradation products D-dimer (D-dimer) and FDP-E show strong correlation in diagnosing thrombotic diseases. However, discrepancies in D-dimer levels may indicate conditions like disseminated intravascular coagulation or hyper-fibrinolytic states.

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Area of Science:

  • Hematology
  • Clinical Chemistry
  • Thrombosis Research

Background:

  • Fibrin degradation products D-dimer (D-dimer) are crucial biomarkers for thrombotic diseases.
  • Secondary fibrinolysis often accompanies thrombotic conditions, necessitating accurate diagnostic markers.
  • Understanding the relationship between D-dimer and other fibrinolysis markers is vital for clinical application.

Observation:

  • A strong linear correlation (r = 0.9269) was found between FDP-E and D-dimer concentrations in 630 patient samples.
  • Thirteen cases exhibited significant dissociation between D-dimer and FDP-E levels.
  • Group A (4 cases) showed higher D-dimer than expected, while Group B (9 cases) showed lower D-dimer than expected.

Findings:

  • All Group A patients were diagnosed with disseminated intravascular coagulation (DIC).

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  • Group B patients included those with widespread cancer metastasis or urokinase treatment.
  • Analysis of AT III/alpha 2 PI and PIC/TAT ratios suggested a hyper-fibrinolytic state in 4 of 9 Group B patients.

    • Implications:

    • Dissociation between D-dimer and FDP-E can indicate specific clinical conditions beyond simple thrombotic disease.
    • Elevated D-dimer relative to FDP-E may suggest DIC.
    • Lower D-dimer relative to FDP-E could indicate a hyper-fibrinolytic state, potentially linked to cancer or specific treatments.