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Final height in patients perinatally infected with the human immunodeficiency virus

S Stagi1, L Galli, C Cecchi

  • 1Department of Paediatrics, Anna Meyer Children's University Hospital, Florence, Italy. stefano.stagi@yahoo.it

Hormone Research in Paediatrics
|June 3, 2010
PubMed

Insights

Children with perinatal human immunodeficiency virus (HIV) infection often have reduced final height compared to their target height. Accumulated growth deficits during childhood and adolescence may contribute to this reduced final height in HIV-infected individuals.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Endocrinology

Background:

  • Final height data are lacking for children with human immunodeficiency virus (HIV) infection.
  • Understanding growth patterns in HIV-infected children is crucial for clinical management.

Purpose of the Study:

  • To evaluate auxological data up to final height in a cohort of perinatally HIV-infected children.
  • To determine factors influencing final height in this population.

Main Methods:

  • Retrospective analysis of auxological data in 95 Caucasian patients (median age 17.5 years) with perinatal HIV infection.
  • Evaluation of prepubertal height (PrH), height velocity (HV), final height (FH), target height (TH), and predicted adult height (PAH) as standard deviation (SD) scores.

Main Results:

  • Patients exhibited significantly reduced PrH and FH compared to their TH (p < 0.001).
  • Age at puberty onset correlated negatively with PrH (p = 0.002) and CD4+ cell percentage (p < 0.01).
  • Height velocity (HV) correlated significantly with viremia (p = 0.001) but not CD4+ cell percentage.

Conclusions:

  • Perinatally HIV-infected patients achieve a final height significantly reduced and not aligned with their target height.
  • Growth deficits accumulated during childhood and adolescence appear to contribute to reduced final height in HIV-infected children.
Abstract

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