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Updated: Jun 12, 2026

Human Circadian Phenotyping and Diurnal Performance Testing in the Real World
Published on: April 7, 2020
Longitudinal associations between endogenous melatonin production and reported sleep duration from childhood to early
Katharina Diethelm1, Lars Libuda, Katja Bolzenius
1Research Institute of Child Nutrition at Rheinische Friedrich Wilhelms University Bonn, Dortmund, Germany. diethelm @ fke-do.de
Background/Aims:
The study objective was to assess longitudinal associations between melatonin secretion and reported sleep duration from childhood to early adulthood.
Methods:
In the frame of the Dortmund Nutritional and Anthropometric Longitudinally Designed (DONALD) Study, 24-hour melatonin secretion and average daily sleep duration were determined once during childhood (4-< 11 years), adolescence (11-<16 years) and early adulthood (16-19 years) in 52 participants (23 males/29 females) aged 4-19 years. The associations between (1) melatonin secretion and sleep duration in childhood (cross-sectional); (2) melatonin secretion in childhood and sleep duration in early adulthood (prospective), and (3) changes in melatonin secretion and concurrent changes in sleep duration from childhood to early adulthood (concurrent) were analyzed.
Results:
Melatonin secretion was associated with sleep duration in childhood (cross-sectional, 3.5 min/day/10 μg 6-hydroxymelatonin sulfate (6-OHMS)/day, p = 0.009) and tended to predict sleep duration in early adulthood (prospective, 9.8 min/day/10 μg 6-OHMS/day, p = 0.09). An individual increase in melatonin secretion between childhood and early adulthood was associated with a concurrent increase in sleep duration (concurrent, 6.9 min/day/10 μg 6-OHMS/day, p = 0.046).
Conclusion:
Our observational data suggest that pineal production of melatonin in childhood is correlated with alterations in sleep duration until early adulthood. Nevertheless, this observational evidence needs to be verified in clinical studies.
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