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Related Experiment Video

Updated: Jun 12, 2026

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Published on: September 9, 2012

Factor X deficiency presenting with bilateral chronic subdural hematoma.

Senem Senturk¹, Ebru Guzel, Aylin Hasanefendioglu Bayrak

¹Department of Radiology, Medical School, Dicle University, Diyarbakir, Turkey. snmsenturk@gmail.com

Pediatric Neurosurgery

|June 3, 2010

Summary

Factor X deficiency, a rare bleeding disorder, can cause brain bleeds in children. This case highlights imaging of subdural hematomas in an infant with Factor X deficiency, successfully treated with plasma and surgery.

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Last Updated: Jun 12, 2026

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

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Published on: September 9, 2012

Determination of the Procoagulant Activity of Extracellular Vesicle (EV) Using EV-Activated Clotting Time (EV-ACT)

Determination of the Procoagulant Activity of Extracellular Vesicle (EV) Using EV-Activated Clotting Time (EV-ACT)

Published on: August 4, 2023

Area of Science:

Pediatric Hematology
Diagnostic Imaging
Neurology

Background:

Factor X deficiency is a rare inherited coagulation disorder.
Hemorrhagic complications, including central nervous system hematomas, can occur.
Infants and children are particularly vulnerable to these manifestations.

Observation:

A 7-month-old male infant presented with hypoactivity and right hemiparesis.
Cranial computed tomography (CT) and magnetic resonance (MR) imaging revealed bilateral chronic subdural hematomas.
Laboratory results indicated a severe Factor X deficiency (0.7%).

Findings:

Imaging demonstrated bilateral chronic subdural hematomas at varying stages of development.
The patient had a confirmed diagnosis of severe Factor X deficiency.
Successful surgical evacuation of the left-sided hematoma was performed post-plasma replacement.

Implications:

This case underscores the importance of considering coagulation disorders in pediatric intracranial hemorrhages.
CT and MR imaging are crucial for diagnosing and characterizing subdural hematomas.
Prompt diagnosis and treatment, including factor replacement and surgical intervention, lead to favorable outcomes in Factor X deficiency.