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Updated: Jun 12, 2026
Intravascular Delivery of Biologics to the Rat Kidney
Published on: September 1, 2016
Cell proliferation and apoptosis in Wistar rat kidney after renal mass ablation and low-dose irradiation
Marina Aunapuu1, Andres Arend, Mai Ots
1Department of Anatomy, University of Tartu, Estonia. marina.aunapuu@ut.ee
Unlabelled:
Cell proliferation and apoptosis in the remnant rat kidney after treatment with low-dose irradiation was investigated.
Material And Methods:
In the first group (n=9), adult male Wistar rats underwent 5/6 nephrectomy (NPX); in the second group (n=9), NPX was combined with low-dose irradiation. Rats without surgery and irradiation formed the control group (n=9).
Results:
Hypertension and proteinuria induced by NPX were decreased by 3-Gy irradiation. The 5/6 NPX rats showed a dramatic increase in proliferating and apoptotic cells in the glomeruli and in the distal tubules at week 2, which was significantly decreased by low-dose irradiation.
Conclusion:
The data demonstrate that low-dose irradiation is a factor slowing the process of chronic renal injury.
