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Related Experiment Video

Updated: Jun 12, 2026

Induction of Graft-versus-host Disease and In Vivo T Cell Monitoring Using an MHC-matched Murine Model
10:29

Induction of Graft-versus-host Disease and In Vivo T Cell Monitoring Using an MHC-matched Murine Model

Published on: August 29, 2012

Graft-versus-host disease.

S Choi1, P Reddy

  • 1Blood and Marrow Transplantation Program, Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI 48109-0942, USA.

Panminerva Medica
|June 3, 2010
PubMed
Summary
This summary is machine-generated.

Allogeneic hematopoietic cell transplantation (HCT) offers a graft-versus-leukemia effect but is limited by graft-versus-host disease (GVHD). Recent advances enhance understanding of acute GVHD pathophysiology, crucial for improving HCT safety and efficacy.

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Induction and Scoring of Graft-Versus-Host Disease in a Xenogeneic Murine Model and Quantification of Human T Cells in Mouse Tissues using Digital PCR
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Published on: May 23, 2019

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease
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Related Experiment Videos

Last Updated: Jun 12, 2026

Induction of Graft-versus-host Disease and In Vivo T Cell Monitoring Using an MHC-matched Murine Model
10:29

Induction of Graft-versus-host Disease and In Vivo T Cell Monitoring Using an MHC-matched Murine Model

Published on: August 29, 2012

Induction and Scoring of Graft-Versus-Host Disease in a Xenogeneic Murine Model and Quantification of Human T Cells in Mouse Tissues using Digital PCR
06:06

Induction and Scoring of Graft-Versus-Host Disease in a Xenogeneic Murine Model and Quantification of Human T Cells in Mouse Tissues using Digital PCR

Published on: May 23, 2019

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease
08:05

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease

Published on: March 17, 2020

Area of Science:

  • Immunology
  • Hematology
  • Oncology

Background:

  • Allogeneic hematopoietic cell transplantation (HCT) is increasingly used for hematological malignancies.
  • The graft-versus-leukemia (GVL) effect is beneficial, but graft-versus-host disease (GVHD) is a major lethal complication.
  • Novel strategies have expanded HCT indications, particularly for older patients.

Purpose of the Study:

  • To review current and recent advances in understanding the pathophysiology of acute GVHD.
  • To elucidate the complex interactions between donor and host immune responses in GVHD.
  • To explore the role of cytokines, chemokines, and immune cell subsets in GVHD induction and regulation.

Main Methods:

  • Review of current and recent scientific literature on acute GVHD.
  • Analysis of the immunological interactions between donor T cells and host antigen-presenting cells (APCs).
  • Examination of the regulatory roles of cytokines, chemokines, and immune cell subsets in GVHD.

Main Results:

  • GVHD is a complex reaction resulting from donor-host immune interactions.
  • Donor T cell interaction with APCs is fundamental to GVHD induction.
  • A multitude of cytokines, chemokines, and immune cells positively or negatively regulate this interaction.

Conclusions:

  • Understanding the intricate pathophysiology of acute GVHD is critical for improving HCT outcomes.
  • Further research into the cross-talk between immune cells and inflammatory molecules in GVHD is warranted.
  • Advances in GVHD knowledge may lead to safer and more widely applicable HCT therapies.