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Related Concept Videos

Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
Somatic to iPS Cell Reprogramming01:29

Somatic to iPS Cell Reprogramming

Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012 for this...
Methods of Nuclear Reprogramming01:24

Methods of Nuclear Reprogramming

Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for injury repair.
EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...

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Related Experiment Video

Updated: Jun 12, 2026

In vivo Reprogramming of Adult Somatic Cells to Pluripotency by Overexpression of Yamanaka Factors
12:12

In vivo Reprogramming of Adult Somatic Cells to Pluripotency by Overexpression of Yamanaka Factors

Published on: December 17, 2013

Exploiting pluripotency for therapeutic gain.

Wenbin Deng1

  • 1Department of Cell Biology and Human Anatomy, Institute of Pediatric Regenerative Medicine, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA. wbdeng@ucdavis.edu

Panminerva Medica
|June 3, 2010
PubMed
Summary
This summary is machine-generated.

Induced pluripotent stem cells (iPSCs) offer a promising alternative to human embryonic stem cells (hESCs) for disease research and regenerative medicine. This technology allows for patient-specific cell lines, potentially overcoming immune rejection issues in future therapies.

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A Two-Step Strategy that Combines Epigenetic Modification and Biomechanical Cues to Generate Mammalian Pluripotent Cells
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A Two-Step Strategy that Combines Epigenetic Modification and Biomechanical Cues to Generate Mammalian Pluripotent Cells

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Reprogramming Induced Pluripotent Stem Cell Lines from Frozen Buffy Coat Samples
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Reprogramming Induced Pluripotent Stem Cell Lines from Frozen Buffy Coat Samples

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Last Updated: Jun 12, 2026

In vivo Reprogramming of Adult Somatic Cells to Pluripotency by Overexpression of Yamanaka Factors
12:12

In vivo Reprogramming of Adult Somatic Cells to Pluripotency by Overexpression of Yamanaka Factors

Published on: December 17, 2013

A Two-Step Strategy that Combines Epigenetic Modification and Biomechanical Cues to Generate Mammalian Pluripotent Cells
08:01

A Two-Step Strategy that Combines Epigenetic Modification and Biomechanical Cues to Generate Mammalian Pluripotent Cells

Published on: August 29, 2020

Reprogramming Induced Pluripotent Stem Cell Lines from Frozen Buffy Coat Samples
09:29

Reprogramming Induced Pluripotent Stem Cell Lines from Frozen Buffy Coat Samples

Published on: April 10, 2026

Area of Science:

  • Stem Cell Biology
  • Regenerative Medicine
  • Genetics

Background:

  • Human embryonic stem cells (hESCs) are the gold standard for pluripotency research but have limitations regarding genetic diversity and ethical considerations.
  • Traditional hESC generation relies on IVF embryos, hindering the creation of patient-specific or disease-specific cell lines.
  • Induced pluripotent stem cells (iPSCs) are generated by reprogramming somatic cells, offering an alternative not derived from embryos.

Purpose of the Study:

  • To explore the potential of induced pluripotent stem cells (iPSCs) as a tool for disease modeling, drug discovery, and regenerative medicine.
  • To highlight the advantages of iPSCs, such as generating patient-specific cell lines for personalized medicine and reducing immune rejection.
  • To discuss the ongoing advancements and challenges in iPSC technology.

Main Methods:

  • Reprogramming of human somatic cells into pluripotent stem cells using defined factors.
  • Comparison of iPSCs' developmental potential with authentic hESCs.
  • Application of iPSCs for disease modeling, drug discovery, and regenerative medicine.

Main Results:

  • iPSCs exhibit similar developmental potential to hESCs.
  • iPSC technology enables the generation of genetically diverse, patient-specific cell lines.
  • Recent research has provided insights into the safety, utility, and efficiency of iPSCs.

Conclusions:

  • iPSCs represent a significant breakthrough, offering a powerful platform for studying diseases and developing new therapies.
  • The ability to generate patient-specific iPSCs holds great promise for personalized medicine and overcoming immune rejection.
  • Despite current limitations in efficiency and safety, iPSCs are paving the way for novel therapeutic applications.