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Updated: Jun 12, 2026

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring
Published on: December 14, 2020
[Voice disturbances in young children with gastroesophageal reflux disease]
Insights
Voice disturbances in young children are often linked to laryngoesophageal reflux. Early endoscopic examination of the larynx is crucial for diagnosing this condition in children experiencing dysphonia.
Area of Science:
- Pediatric Gastroenterology
- Otolaryngology
- Speech-Language Pathology
Background:
- Gastroesophageal reflux disease (GERD) can manifest with atypical symptoms in infants and young children.
- Laryngoesophageal reflux (LER) is a significant concern, potentially impacting laryngeal health and voice quality in pediatric populations.
Purpose of the Study:
- To investigate the relationship between voice disturbances and gastroesophageal reflux disease in young children.
- To identify the key laryngeal signs associated with LER in this age group.
Main Methods:
- A diagnostic algorithm incorporating direct transnasal laryngoscopy, esophagogastroduodenoscopy, 24-hour esophageal pH monitoring, and esophageal mucosal biopsy.
- Acoustic voice analysis was performed on 26 children aged 8 months to 3 years with reported voice disturbances.
- Detailed examination of laryngeal structures including arytenoid cartilages, interarytenoid space, and vocal cords.
Main Results:
- Dysphonia, laryngeal edema, hyperemia, and altered mucosal light reflexes were the primary indicators of LER.
- These signs were observed in the arytenoid cartilages, interarytenoid space, and vocal cords.
- Voice disturbances were identified as a prevalent symptom of LER in the studied pediatric cohort.
Conclusions:
- Voice disturbances are a common and significant symptom of laryngoesophageal reflux in young children.
- Prompt endoscopic evaluation of the larynx is essential for all children presenting with dysphonia to rule out LER.
- Early diagnosis and management of LER can potentially prevent long-term laryngeal complications.
Abstract:
The objective of the present work was to study voice disturbances in young children with gastroesophageal reflux disease. Diagnostic algorithm included direct transnasal examination of the larynx using an Olympus fibroscope (Japan), fibrogastroduodenoscopy, 24-hour potentiometry, biopsy of oesophageal mucosa, and acoustic analysis of the voice. A total of 26 children at the age from 8 months to 3 years with voice disturbances were examined, including 12 children below one year, 5 between 1 and 2 years, and 9 between 2 and 3 years. The main signs of laryngoesophageal reflux were dysphonia, oedema, hyperemia, and altered light reflex of mucous membrane of arytenoid cartilages, interarytenoid space, and vocal cords. It is concluded that voice disturbances are the most common symptoms of laryngoesophageal reflux in young children which necessitates the earliest possible endoscopic study of the larynx in all cases of dysphonia.
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