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Related Concept Videos

Asepsis01:28

Asepsis

The condition of being free from disease-causing living pathogens is asepsis. Aseptic techniques include a set of standard practices to achieve asepsis. An example is the regular environmental cleaning of all parts of the healthcare facility and hand hygiene at home before preparing or eating food. Medical and surgical asepsis in healthcare practice protects patients from harmful pathogens, minimizes the risk of contamination of susceptible sites, and reduces the risk of infection transmission.
Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...

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Related Experiment Video

Updated: Jun 12, 2026

Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis
05:28

Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis

Published on: December 9, 2022

Early source control in sepsis.

Jan J De Waele1

  • 1Department of Critical Care Medicine, Ghent University Hospital, De Pintelaan 185, 9000, Gent, Belgium. Jan.DeWaele@UGent.be

Langenbeck'S Archives of Surgery
|June 3, 2010
PubMed
Summary
This summary is machine-generated.

Early source control is crucial for severe sepsis management. Prompt intervention, often within hours, improves patient outcomes and should be prioritized after diagnosis.

More Related Videos

A Data-Driven Approach to Quantifying Immune States in Sepsis
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A Data-Driven Approach to Quantifying Immune States in Sepsis

Published on: February 7, 2025

Related Experiment Videos

Last Updated: Jun 12, 2026

Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis
05:28

Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis

Published on: December 9, 2022

A Data-Driven Approach to Quantifying Immune States in Sepsis
07:42

A Data-Driven Approach to Quantifying Immune States in Sepsis

Published on: February 7, 2025

Area of Science:

  • Critical Care Medicine
  • Infectious Diseases
  • Surgical Management

Background:

  • Severe sepsis and septic shock necessitate timely interventions, including fluid resuscitation and antibiotics.
  • Early source control is recognized as vital but lacks clear definition and established protocols.

Purpose of the Study:

  • To review the role and timing of early source control in severe sepsis management.
  • To clarify the definition and clinical utility of early source control interventions.

Main Methods:

  • Literature review and synthesis of current evidence on source control in severe sepsis.
  • Analysis of the rationale and obstacles related to delaying source control.
  • Proposal of a tiered classification for source control urgency.

Main Results:

  • While early source control is essential, its precise timing and definition remain debated.
  • Delaying source control in non-critically ill patients for up to 24 hours lacks strong pathophysiological justification.
  • Numerous obstacles exist, but most patients can undergo source control within hours after initial stabilization.

Conclusions:

  • Source control is a cornerstone in managing sepsis and septic shock.
  • Early source control should be implemented promptly upon diagnosis in most patients.
  • A patient-specific, timely approach to source control is recommended.