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[Microalbuminuria in essential arterial hypertension]
J Redón1, J M Pascual, A Miralles
1Unidad de Hipertensión (Servicio de Medicina Interna), Hospital de Sagunto, Valencia.
Medicina Clinica
|April 13, 1991
Summary
Microalbuminuria (mAlb) indicates more severe essential hypertension (HT). This urinary albumin excretion (UAE) marker aids in evaluating hypertensive patients and may correlate with left ventricular mass in males.
Area of Science:
- Nephrology
- Cardiology
- Hypertension Research
Background:
- Essential hypertension (HT) is a prevalent cardiovascular risk factor.
- Microalbuminuria (mAlb) is an early indicator of kidney damage.
- The relationship between mAlb and HT severity requires further investigation.
Purpose of the Study:
- To evaluate the occurrence of microalbuminuria (mAlb) in patients with essential hypertension (HT).
- To determine the correlation between urinary albumin excretion (UAE) and blood pressure parameters.
- To assess the association between mAlb and cardiac structural changes.
Main Methods:
- 100 hypertensive patients (56 males, mean age 39) were studied.
- Urinary albumin excretion (UAE) measured via nephelometry; blood pressure via noninvasive ambulatory recording (NIAR).
- Echocardiography assessed left ventricular mass; patients categorized by HT severity and WHO stage.
Main Results:
- UAE correlated with 24-hour systolic and diastolic blood pressure (SBP24h, DBP24h).
- Higher UAE levels observed in moderate HT compared to mild or borderline HT (p < 0.01).
- Increased UAE associated with greater left ventricular mass index in males (chi-square p < 0.05).
Conclusions:
- Increased microalbuminuria (mAlb) is linked to more severe essential hypertension (HT).
- Urinary albumin excretion (UAE) serves as a valuable marker in hypertensive patient evaluation.
- Findings suggest mAlb may reflect underlying cardiovascular impact in HT.