Related Experiment Video
Updated: Jun 12, 2026
07:20
Studies on the Anti-Inflammatory Effect of Xiaoyao Pills in The Treatment of Postmenopausal Osteoporosis in Mice
Published on: August 23, 2024
Therapeutic options in osteoporosis.
Ligia J Dominguez1, Rosalinda Scalisi, Mario Barbagallo
1Geriatric Unit, Department of Clinical Medicine and Emergent Pathologies, University of Palermo, Italy.
Acta Bio-Medica : Atenei Parmensis
|June 4, 2010
Summary
Osteoporosis prevention requires lifelong healthy habits like diet and exercise. Effective management includes assessing fracture risk and using nonpharmacological and pharmacological treatments to reduce fractures.
Area of Science:
- Bone Health and Osteoporosis Research
- Public Health and Geriatrics
Background:
- Osteoporosis is a global health issue causing bone fragility and fractures, particularly in aging populations.
- Fracture risk increases with age, necessitating early and lifelong prevention strategies.
- Despite available treatments, osteoporosis management and fracture risk assessment remain suboptimal.
Purpose of the Study:
- To review effective nonpharmacological and pharmacological interventions for reducing osteoporotic fractures.
- To highlight the importance of a comprehensive approach to osteoporosis management.
- To emphasize the need for interventions that reduce fracture incidence, not just bone mineral density.
Main Methods:
- Review of available scientific literature on osteoporosis interventions.
- Analysis of nonpharmacological strategies including diet, physical activity, and fall prevention.
- Evaluation of pharmacological treatments focusing on fracture risk reduction and safety.
Main Results:
- Lifelong healthy lifestyle choices, including balanced nutrition and physical activity, are crucial for bone health.
- Adequate vitamin D status and fall prevention are essential for older adults at high risk.
- Both nonpharmacological and pharmacological interventions are necessary for effective fracture protection, with a focus on reducing fracture incidence.
Conclusions:
- Osteoporosis management requires a multifaceted approach, integrating lifestyle modifications with targeted treatments.
- Interventions must demonstrate efficacy in reducing fracture rates, considering individual safety profiles.
- Improving the assessment and implementation of evidence-based osteoporosis treatments is critical to mitigate the global burden of fractures.
Related Concept Videos
01:31Osteoclasts in Bone Remodeling
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
01:29Bone Disorders
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
01:40Bone Remodeling
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
01:25Role of Vitamins in Maintaining Bone Health
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
01:31Bone Remodeling and Repair
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
01:17Hormones and Bone Tissue
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...