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Related Concept Videos

Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
Methods of Medium Optimization01:28

Methods of Medium Optimization

Optimizing growth media enhances microbial proliferation and maximizes product yield. Statistical experimental design methodologies provide structured and reproducible approaches, offering progressively higher levels of robustness and efficiency.The One-Factor-at-a-Time (OFAT) MethodThe One-Factor-at-a-Time (OFAT) method involves adjusting a single variable while keeping all others constant. However, it cannot detect interactions between variables, often leading to suboptimal outcomes when...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

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Updated: Jun 12, 2026

A Rat Model of Compound Acne
03:10

A Rat Model of Compound Acne

Published on: November 1, 2024

Optimizing acne therapy with unique vehicles.

Leon Kircik1, Adam Friedman

  • 1Indiana University, Indianapolis, IN, USA.

Journal of Drugs in Dermatology : JDD
|June 4, 2010
PubMed
Summary
This summary is machine-generated.

New micro/nano encapsulation techniques enhance topical acne treatments, improving efficacy and patient compliance. These advanced drug delivery systems overcome skin penetration challenges for better therapeutic outcomes.

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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Area of Science:

  • Dermatology
  • Pharmaceutics
  • Drug Delivery Systems

Background:

  • The stratum corneum presents a significant barrier to cutaneous drug delivery.
  • Acne vulgaris is a complex pilosebaceous unit disease influenced by sebum, desquamation, bacteria, and inflammation.
  • Current topical acne treatments often require combination therapy or systemic agents for efficacy.

Purpose of the Study:

  • To explore novel topical drug delivery systems for enhanced acne vulgaris treatment.
  • To address the limitations of existing topical regimens in penetrating the stratum corneum.
  • To investigate the potential of micro/nano encapsulation and reactive vehicles for improved therapeutic outcomes.

Main Methods:

  • Utilizing micro/nano encapsulation of active ingredients like benzoyl peroxide and tretinoin.
  • Developing vehicles with inherent biological reactivity and permeation-enhancing properties.
  • Evaluating the physical and optical properties of novel delivery systems.

Main Results:

  • Micro/nano encapsulation improves the efficacy of topical acne therapeutics.
  • Advanced delivery systems minimize adverse events and enhance patient compliance.
  • Vehicles with biological reactivity and permeation enhancement show improved performance over conventional methods.

Conclusions:

  • Innovative topical drug delivery, particularly micro/nano encapsulation, offers a promising approach to overcoming the stratum corneum barrier.
  • These advancements lead to improved efficacy and tolerability in treating acne vulgaris.
  • Continued research into novel vehicles will drive the future of topical dermatological therapeutics.