Enantioselective total synthesis of the selective PI3 kinase inhibitor liphagal
Enrique Alvarez-Manzaneda1, Rachid Chahboun, Esteban Alvarez
1Departamento de Química Orgánica, Facultad de Ciencias, Instituto de Biotecnología, Universidad de Granada, 18071 Granada, Spain. eamr@ugr.es
Abstract:
The enantioselective total synthesis of liphagal, a selective inhibitor of PI3K α isolated from the marine sponge Aka coralliphaga, has been achieved. The novel tetracyclic "liphagane" skeleton is formed in one step, after the hydrogenation of a dihydroxydrimane phenol benzyl ether in the presence of cationic resin.
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