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Related Concept Videos

Seizures: Classification01:13

Seizures: Classification

Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Brain Imaging01:14

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).

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Related Experiment Video

Updated: Jun 12, 2026

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy
08:23

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

Published on: November 13, 2016

Voxel-based morphometry and epilepsy.

Clarissa Lin Yasuda1, Luiz Eduardo Betting, Fernando Cendes

  • 1University of Campinas, SP, Brazil.

Expert Review of Neurotherapeutics
|June 4, 2010
PubMed
Summary
This summary is machine-generated.

Voxel-based morphometry reveals widespread gray and white matter abnormalities in epilepsy. These brain changes in temporal lobe and generalized epilepsies correlate with disease severity and outcomes.

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Area of Science:

  • Neuroimaging
  • Neurology
  • Radiology

Background:

  • Voxel-based morphometry (VBM) is an automated MRI analysis technique for studying brain morphology.
  • It is frequently applied to neurological disorders, including various epilepsy syndromes.

Purpose of the Study:

  • To review the application of VBM in epilepsy research.
  • To highlight findings in temporal lobe epilepsy (TLE) and generalized epilepsies (GE).

Main Methods:

  • VBM analysis of brain MRI scans.
  • Comparison of gray and white matter volumes in patient cohorts.

Main Results:

  • In TLE, VBM identified gray/white matter atrophy extending beyond the hippocampus, linked to seizure frequency, duration, cognitive issues, and surgical outcomes.
  • In GE, VBM detected gray matter abnormalities in the thalamus and frontal cortex, implicating thalamocortical networks.

Conclusions:

  • VBM is a valuable tool for understanding brain alterations in epilepsy.
  • Widespread structural abnormalities and thalamocortical network involvement are key features in different epilepsy types.