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Necrotizing pancreatitis due to simian adenovirus type 31 in a rhesus monkey
Abstract:
Simian adenovirus type 31 was isolated from pancreatic tissue of an 8-year-old male rhesus monkey that died as the result of acute necrotizing pancreatitis. Histologically, the pancreas showed wide-spread necrosis, extensive infiltration of polymorphonuclear leukocytes, and nuclear inclusions in pancreatic acinar cells. Large numbers of adenovirus particles were demonstrable in the acinar cells by electron microscopy. This is the second case of adenovirus-associated pancreatitis we have found in rhesus monkeys and the first case in which we attempted to isolate the virus. Our data indicate that adenovirus pancreatitis is a distinct entity in rhesus monkeys and may occur with greater frequency than is generally believed.
Insights
Simian adenovirus type 31 caused acute necrotizing pancreatitis in a rhesus monkey. This finding suggests adenovirus pancreatitis may be a distinct and potentially common condition in rhesus monkeys.
Area of Science:
- Veterinary Pathology
- Virology
- Primate Medicine
Background:
- Acute necrotizing pancreatitis is a severe condition in rhesus monkeys.
- Adenovirus infections are known in simian populations.
Purpose of the Study:
- To identify the causative agent of acute necrotizing pancreatitis in a rhesus monkey.
- To investigate the role of simian adenovirus in primate pancreatitis.
Main Methods:
- Isolation of simian adenovirus type 31 from pancreatic tissue.
- Histopathological examination of pancreatic tissue.
- Electron microscopy to visualize adenovirus particles.
Main Results:
- Simian adenovirus type 31 was isolated from an 8-year-old male rhesus monkey with acute necrotizing pancreatitis.
- Histology revealed widespread pancreatic necrosis, inflammation, and nuclear inclusions.
- Electron microscopy confirmed the presence of numerous adenovirus particles within acinar cells.
Conclusions:
- Adenovirus pancreatitis is identified as a distinct pathological entity in rhesus monkeys.
- This case represents the first successful isolation of adenovirus associated with pancreatitis in this species.
- Adenovirus-associated pancreatitis may occur more frequently in rhesus monkeys than previously recognized.