Related Experiment Video
Updated: Jun 12, 2026
05:58
Proplatelet Formation Dynamics of Mouse Fresh Bone Marrow Explants
Published on: May 20, 2021
The role of platelets in bone remodeling
Pooneh Salari Sharif1, Mohammad Abdollahi
1Medical Ethics and History of Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran. poonehsalari@gmail.com
Inflammation & Allergy Drug Targets
|June 4, 2010
Summary
Platelets influence bone health and osteoporosis through growth factors and immune agents. Further research is needed, but platelets may offer therapeutic targets for osteoporosis prevention and treatment.
Area of Science:
- Biomedical Science
- Cell Biology
- Osteoporosis Research
Background:
- Platelets are crucial for hemostasis, wound healing, and bone fracture repair.
- Inflammation and oxidative stress are key factors in osteoporosis development.
- Platelet degranulation releases factors impacting bone metabolism, but their net effect remains unclear.
Purpose of the Study:
- To review existing studies on the role of platelets in bone health.
- To investigate the relationship between platelets, inflammation, and osteoporosis.
- To explore potential therapeutic applications of platelets in bone disorders.
Main Methods:
- Systematic literature search of Scopus, PubMed, and Web of Science databases.
- Keywords included: platelets, osteoblasts, osteoclasts, bone, antiplatelet drugs, bone formation, bone resorption.
- Analysis of in vivo and in vitro studies examining platelet function in bone metabolism.
Main Results:
- Platelets release various growth factors and immune/inflammatory agents.
- These factors can influence bone formation and resorption processes.
- Limited in vivo and in vitro studies currently exist.
Conclusions:
- Platelets and their derived factors represent potential targets for osteoporosis therapy.
- Understanding platelet-immune interactions is vital for developing preventive strategies.
- Further research is warranted to fully elucidate platelet's role in bone health and disease.
Related Concept Videos
01:31Osteoclasts in Bone Remodeling
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
01:40Bone Remodeling
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
01:18Structure and Function of Platelets
The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...
01:22Formation of the Platelet Plug
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
01:27Fractures: Bone Repair
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
01:31Bone Remodeling and Repair
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...