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Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells

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Published on: May 19, 2020

Tuberculous meningitis presenting as isolated interhemispheric exudates.

R D Bharath¹, S Sinha, M K Vasudev

¹Department of Neuro Imaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Bangalore, India. drrosedawn@yahoo.com

Journal of Medical Imaging and Radiation Oncology

|June 4, 2010

Summary

Tuberculosis cases are rising globally, leading to more unusual presentations of tuberculous meningitis (TBM). This study details a rare anterior interhemispheric TBM variant, highlighting key imaging findings for earlier diagnosis and treatment.

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Area of Science:

Neurology
Infectious Diseases
Radiology

Background:

Tuberculosis (TB) is a growing global health concern.
Tuberculous meningitis (TBM) is a severe form of TB affecting the central nervous system.
Increasing incidence of TB necessitates awareness of its diverse clinical and radiological presentations.

Purpose of the Study:

To describe a previously undocumented variant of TBM.
To detail the specific imaging characteristics of anterior interhemispheric TBM.
To emphasize the importance of recognizing uncommon radiological findings for timely TBM diagnosis.

Main Methods:

Retrospective case series analysis.
Review of neuroimaging findings in five patients diagnosed with TBM.
Correlation of radiological features with clinical presentation.

Main Results:

Identification of a distinct anterior interhemispheric TBM pattern.
Predominant meningeal involvement within the anterior interhemispheric fissure observed.
Minimal enhancement in basal cisterns noted as a characteristic finding in this variant.

Conclusions:

The anterior interhemispheric TBM is a newly described radiological variant.
Recognizing this specific pattern aids in the early diagnosis of TBM.
Awareness of diverse TBM imaging manifestations is crucial for effective patient management.