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Mastectomy as an adjunct to combination chemotherapy
Archives of Surgery (Chicago, Ill. : 1960)
|March 1, 1978
Summary
Combination chemotherapy followed by mastectomy effectively treated advanced breast cancer, leading to tumor regression and disease-free survival. This approach simplifies surgery and avoids complications for patients with locally advanced primary tumors.
Area of Science:
- Oncology
- Surgical Oncology
- Medical Oncology
Background:
- Locally advanced primary breast tumors present surgical challenges.
- Metastatic breast carcinoma requires multimodal treatment strategies.
Purpose of the Study:
- To evaluate the efficacy of neoadjuvant chemotherapy followed by mastectomy in patients with metastatic breast carcinoma and locally advanced primary tumors.
- To assess the feasibility and outcomes of this combined treatment approach.
Main Methods:
- Three patients with metastatic breast carcinoma and untreated locally advanced primary tumors received combination chemotherapy.
- Following chemotherapy, patients underwent hygienic mastectomy.
- Postoperative systemic chemotherapy was administered.
Main Results:
- Chemotherapy induced significant regression of primary tumors, enabling simpler mastectomy without skin grafts.
- No serious postoperative complications or delays in systemic chemotherapy resumption occurred.
- Postoperative chemotherapy led to complete disappearance of distant metastases, with patients remaining disease-free for 21, 10, and 7 months.
- One patient with inflammatory carcinoma showed a positive response.
Conclusions:
- Neoadjuvant chemotherapy followed by mastectomy is a viable approach for managing locally advanced primary breast tumors in metastatic settings.
- This strategy simplifies surgical resection and facilitates timely adjuvant therapy.
- The combined approach shows promise for patients with inflammatory and Stage III breast cancer.