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Related Experiment Video

Updated: Jun 12, 2026

Continuous Theta Burst Stimulation of the Posterior Medial Frontal Cortex to Experimentally Reduce Ideological Threat Responses

Continuous Theta Burst Stimulation of the Posterior Medial Frontal Cortex to Experimentally Reduce Ideological Threat Responses

Published on: September 28, 2018

If good things come from above, do bad things come from below?

David M Findlay

Arthritis Research & Therapy

|June 4, 2010

Summary

Subchondral bone lesions may drive osteoarthritis progression. New research shows these bone marrow lesions predict cartilage loss and cyst formation, suggesting a "bottom-up" disease mechanism.

Area of Science:

Orthopedics
Rheumatology
Bone Biology

Background:

Articular cartilage health is typically associated with factors from synovial fluid.
The role of subchondral bone in osteoarthritis (OA) initiation and progression is increasingly recognized.
Advanced tools now allow for probing early OA events within the subchondral bone compartment.

Discussion:

Bone marrow lesions (BMLs) in the subchondral bone are investigated as potential drivers of OA.
The study by Tanamas and co-workers provides evidence linking BMLs to cartilage degradation.
BMLs were found to be predictive of both cartilage loss and subchondral cyst formation.

Key Insights:

Subchondral bone marrow lesions are significant predictors of osteoarthritis progression.

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Methods to Explore the Influence of Top-down Visual Processes on Motor Behavior

Methods to Explore the Influence of Top-down Visual Processes on Motor Behavior

Published on: April 16, 2014

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Continuous Theta Burst Stimulation of the Posterior Medial Frontal Cortex to Experimentally Reduce Ideological Threat Responses

Continuous Theta Burst Stimulation of the Posterior Medial Frontal Cortex to Experimentally Reduce Ideological Threat Responses

Published on: September 28, 2018

Methods to Explore the Influence of Top-down Visual Processes on Motor Behavior

Methods to Explore the Influence of Top-down Visual Processes on Motor Behavior

Published on: April 16, 2014

Evidence suggests a "bottom-up" mechanism in OA, originating from subchondral bone.

BMLs are associated with distinct pathological outcomes, including cartilage loss and cyst development.

Outlook:

Further research is needed to elucidate the specific factors and mechanisms within BMLs that contribute to OA.
Understanding the role of subchondral bone may lead to novel therapeutic targets for osteoarthritis.
This study opens new avenues for investigating the pathogenesis of osteoarthritis from the subchondral bone perspective.