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Related Concept Videos

Structures of the Endocrine System00:59

Structures of the Endocrine System

The intricate framework of the endocrine system encompasses a diverse array of glands, with their target tissues and organs strategically distributed throughout the body. Central to this network are the endocrine glands, specialized structures that lack ducts and release hormones directly into the interstitial fluid. Notably, the hypothalamus, a vital neuroendocrine organ situated in the brain, governs neural functions and serves as a potent source of hormonal regulation. Near the hypothalamus...
An Overview of the Endocrine System01:10

An Overview of the Endocrine System

The endocrine system, a complex network of glands, orchestrates physiological balance within the body through the production and secretion of hormones. These hormones are chemical messengers in intercellular communication, acting as conduits between the secretory cells and distant target sites. They traverse the circulatory system by being released into the extracellular fluid, and their impact is specific to cells possessing receptors for a particular hormone.
The endocrine system collaborates...
What is the Endocrine System?00:46

What is the Endocrine System?

The endocrine system sends hormones—chemical signals—through the bloodstream to target cells—the cells the hormones selectively affect. These signals are produced in endocrine cells, secreted into the extracellular fluid, and then diffuse into the blood. Eventually, they diffuse out of the blood and bind to target cells which have specialized receptors to recognize the hormones.
The Endocrine System01:29

The Endocrine System

The endocrine system is an extensive network of glands – organs or tissues in the body that create chemicals that control many bodily functions, that secrete hormones, which are chemical messengers that play essential roles in regulating various bodily functions. These hormones are secreted into the bloodstream and travel throughout the body. They require specific receptors to convey signals to cells possessing these corresponding receptors. This complex signaling mechanism ensures that every...
Endocrine Signaling01:45

Endocrine Signaling

Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.
Endocrine Signaling01:45

Endocrine Signaling

Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.

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Related Experiment Video

Updated: Jun 12, 2026

Mixed Primary Cultures of Murine Small Intestine Intended for the Study of Gut Hormone Secretion and Live Cell Imaging of Enteroendocrine Cells
09:16

Mixed Primary Cultures of Murine Small Intestine Intended for the Study of Gut Hormone Secretion and Live Cell Imaging of Enteroendocrine Cells

Published on: April 20, 2017

An enteroendocrine full package solution.

Thue W Schwartz1, Birgitte Holst

  • 1Laboratory for Molecular Pharmacology, Department of Neuroscience and Pharmacology, The University of Copenhagen, The Panum Institute, Blegdamsvej 3, DK-2200 Copenhagen, Denmark. tws@sund.ku.dk

Cell Metabolism
|June 4, 2010
PubMed
Summary

Enteroendocrine L cells communicate with enterocytes via a novel two-way paracrine loop. This reveals intricate interplay between lipid and peptide signaling in the intestine.

More Related Videos

Combining Human Organoids and Organ-on-a-Chip Technology to Model Intestinal Region-Specific Functionality
10:56

Combining Human Organoids and Organ-on-a-Chip Technology to Model Intestinal Region-Specific Functionality

Published on: May 5, 2022

Related Experiment Videos

Last Updated: Jun 12, 2026

Mixed Primary Cultures of Murine Small Intestine Intended for the Study of Gut Hormone Secretion and Live Cell Imaging of Enteroendocrine Cells
09:16

Mixed Primary Cultures of Murine Small Intestine Intended for the Study of Gut Hormone Secretion and Live Cell Imaging of Enteroendocrine Cells

Published on: April 20, 2017

Combining Human Organoids and Organ-on-a-Chip Technology to Model Intestinal Region-Specific Functionality
10:56

Combining Human Organoids and Organ-on-a-Chip Technology to Model Intestinal Region-Specific Functionality

Published on: May 5, 2022

Area of Science:

  • Gastroenterology
  • Cell Biology
  • Endocrinology

Background:

  • Enteroendocrine L cells play a crucial role in regulating intestinal functions.
  • Existing knowledge on L cell regulation primarily focused on endocrine and neuronal signaling pathways.

Discussion:

  • Cox et al. (2010) identified a previously unrecognized two-way paracrine signaling loop between enteroendocrine L cells and adjacent enterocytes.
  • This paracrine loop involves the exchange of messenger molecules, suggesting a complex local regulatory network within the intestinal epithelium.

Key Insights:

  • The study highlights a sophisticated local interplay between lipid and peptide messenger systems in the intestine.
  • Both paracrine, endocrine, and neuronal pathways are implicated in this complex signaling network, underscoring the multifaceted regulation of intestinal homeostasis.

Outlook:

  • Further research is needed to fully elucidate the specific molecules involved in this paracrine loop and their precise functions.
  • Understanding this intricate signaling network may offer new therapeutic targets for various gastrointestinal disorders.