Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
Humoral Immune Responses01:36

Humoral Immune Responses

Overview
What is the Immune System?01:38

What is the Immune System?

Overview
Immunological Memory01:23

Immunological Memory

Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature is...
The Parasympathetic Nervous System01:14

The Parasympathetic Nervous System

Overview
Introduction to Innate and Adaptive Immunity01:21

Introduction to Innate and Adaptive Immunity

The human immune system is a complex defense mechanism that protects the body from harmful pathogens and foreign substances. It comprises two crucial components: innate and adaptive immunity.
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Real-world clinical evaluation of the Inflammatix TriVerity test for sepsis at the emergency department: an Acutelines study.

Internal and emergency medicine·2026
Same author

Authors reply: "VExUS-ED: Early venous congestion is associated with clinical fluid overload in patients with sepsis".

Journal of critical care·2026
Same author

SOFA-2 represents meaningful progress toward a more inclusive and equitable global sepsis assessment framework.

Frontiers in medicine·2026
Same author

Development, validation, and implementation of the antibody-secreting cell maturity index: Universal prediction of human plasma cell maturity.

iScience·2026
Same author

Reconsidering IVC dilatation in VExUS: The role of organ venous Doppler during early sepsis resuscitation.

Journal of critical care·2026
Same author

Efgartigimod in Sjögren's disease: a phase 2, randomised, placebo-controlled, parallel-group, double-blinded, proof-of-concept study (RHO).

Annals of the rheumatic diseases·2026

Related Experiment Video

Updated: Jun 12, 2026

An Experimental Study on Colorado Potato Beetle Hibernation Under Natural Conditions
07:44

An Experimental Study on Colorado Potato Beetle Hibernation Under Natural Conditions

Published on: November 17, 2023

Hibernation: the immune system at rest?

Hjalmar R Bouma1, Hannah V Carey, Frans G M Kroese

  • 1Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, The Netherlands. h.r.bouma@med.umcg.nl

Journal of Leukocyte Biology
|June 4, 2010
PubMed
Summary

Mammalian hibernation severely depresses metabolism and immune function, reducing circulating leukocytes and impairing immune responses. This immune suppression during hibernation may increase susceptibility to infections, highlighting the need to understand these physiological changes.

More Related Videos

Unraveling Key Players of Humoral Immunity: Advanced and Optimized Lymphocyte Isolation Protocol from Murine Peyer's Patches
08:25

Unraveling Key Players of Humoral Immunity: Advanced and Optimized Lymphocyte Isolation Protocol from Murine Peyer's Patches

Published on: November 21, 2018

Related Experiment Videos

Last Updated: Jun 12, 2026

An Experimental Study on Colorado Potato Beetle Hibernation Under Natural Conditions
07:44

An Experimental Study on Colorado Potato Beetle Hibernation Under Natural Conditions

Published on: November 17, 2023

Unraveling Key Players of Humoral Immunity: Advanced and Optimized Lymphocyte Isolation Protocol from Murine Peyer's Patches
08:25

Unraveling Key Players of Humoral Immunity: Advanced and Optimized Lymphocyte Isolation Protocol from Murine Peyer's Patches

Published on: November 21, 2018

Area of Science:

  • Immunology
  • Physiology
  • Mammalian Hibernation

Background:

  • Mammalian hibernation involves torpor with severely depressed metabolism and body temperature, punctuated by arousal phases.
  • Hibernation significantly impacts both innate and adaptive immune systems.
  • Reduced immune function during hibernation may elevate infection risk, as seen in White-Nose Syndrome (WNS) in bats.

Purpose of the Study:

  • To investigate the effects of hibernation on mammalian immune function.
  • To elucidate the pathways responsible for reduced immune activity during hibernation.
  • To enhance understanding of immunologic responses during extreme physiological states.

Main Methods:

  • Analysis of circulating leukocyte numbers during hibernation.
  • Assessment of immune parameters including complement levels, LPS response, phagocytotic capacity, cytokine production, lymphocyte proliferation, and antibody production.

Main Results:

  • Torpor phases of hibernation drastically reduce circulating leukocyte counts.
  • Observed changes include lower complement levels and diminished immune responses to stimuli like LPS.
  • Impaired cytokine production, lymphocyte proliferation, and antibody production were noted.

Conclusions:

  • Hibernation leads to a significant suppression of both innate and adaptive immune functions.
  • The reduced immune surveillance during hibernation increases the risk of infections in hibernating mammals.
  • Further research into these pathways is crucial for understanding mammalian immune responses to extreme physiological changes.