Related Experiment Video
Updated: Jun 12, 2026

Exploring the Arginine Methylome by Nuclear Magnetic Resonance Spectroscopy
Published on: December 16, 2021
[Role of arginine in development of biopharmaceuticals]
1Alliance Protein Laboratories, Thousand Oaks, CA 91360, USA. tarakawa2@aol.com
Abstract:
Production, formulation and characterization of proteins play a major role in biotechnology industries. We have shown that aqueous arginine solution increases the solubility of proteins in formulation and purification, suppresses aggregation during refolding and storage and improves performance of column chromatography. Acidic arginine solution now finds application for virus inactivation. I will summarize these various effects of arginine on proteins and viruses and describe the current knowledge of the mechanism of the effects of arginine.
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